A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis

Blandine Rammaert; Pierre-Yves Bochud; Anne-Sophie Brunel; Agnieszka Wojtowicz; Sophie Candon; Maria Pilar Gallego Hernanz; Olivier Lortholary

doi:10.1093/ofid/ofad078

A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis

Open Forum Infect Dis. 2023 Feb 14;10(3):ofad078. doi: 10.1093/ofid/ofad078. eCollection 2023 Mar.

Authors

Blandine Rammaert¹, Pierre-Yves Bochud², Anne-Sophie Brunel², Agnieszka Wojtowicz², Sophie Candon³, Maria Pilar Gallego Hernanz⁴, Olivier Lortholary^{1

5}

Affiliations

¹ Université de Paris Cité, APHP, Service des Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants Malades, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, Paris, France.
² Infectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, CHUV, Lausanne, Switzerland.
³ INSERM U1234, CHU de Rouen Normandie, Université de Rouen Normandie, Rouen, France.
⁴ CHU de Poitiers, Service d'Hématologie Adulte, Poitiers, France.
⁵ Institut Pasteur, CNRS, Département de Mycologie, UMR 2000, Centre National de Référence Mycoses Invasives et Antifongiques, Paris, France.

Abstract

We investigated single nucleotide polymorphisms (SNPs) possibly involved in immune reconstitution inflammatory syndrome of chronic disseminated candidiasis (IRIS-CDC) through a candidate gene approach and a prospective matched-control study. We found that an SNP located in interleukin-1B at rs1143627 was significantly associated with the risk of developing IRIS-CDC.

Keywords: Candida spp; IL-1B; cytokines; genetic polymorphism; immune inflammatory reconstitution syndrome; invasive fungal diseases.