The senile plaque: Morphological differences in APP knock-in mice brains by fixatives

Abstract

The morphology of senile plaques depends on the APP knock-in mice brain fixative. Solid forms of senile plaques were detected in APP knock-in mice after formic acid treatment with Davidson's and Bouin's fluid fixative as the brain of AD patients. Aβ42 was deposited as cored plaques and Aβ38 accumulated around Aβ42.

Keywords: Amyloid β protein; Senile plaque.