Determinants of vitamin D status in patients with hip fracture and in elderly control subjects

Am J Clin Nutr. 1987 Dec;46(6):1005-10. doi: 10.1093/ajcn/46.6.1005.

Abstract

The factors that influence vitamin D status were investigated in 125 patients with hip fracture and in 74 elderly control subjects. The serum concentrations of 25-hydroxyvitamin D [25(OH)D] varied with sunshine score and were paralleled by serum 1,25-dihydroxyvitamin D [1,25(OH)2D]. The control subjects showed a higher sunshine score and higher serum 24(OH)D levels than the patients with hip fracture. Dietary vitamin D intake was similar in both groups (mean 115 IU/d). A positive correlation between vitamin D intake and serum 25(OH)D was observed in the patients with low sunshine exposure. It appeared from this relation that dietary vitamin D intake should be approximately 300 IU/d to maintain an adequate serum (25(OH)D concentration. Vitamin D status was very poor in patients who were institutionalized before hip fracture. Multiple regression analysis on serum 25(OH)D confirmed the primary role of sunshine exposure as determinant of vitamin D status. The principal determinants of serum 1,25(OH)2D were serum 25(OH)D, serum creatinine, and serum phosphate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Calcium, Dietary / administration & dosage
  • Diet*
  • Female
  • Hip Fractures / metabolism*
  • Humans
  • Hydroxycholecalciferols / blood
  • Male
  • Sunlight
  • Vitamin D / administration & dosage
  • Vitamin D / metabolism*

Substances

  • Calcium, Dietary
  • Hydroxycholecalciferols
  • Vitamin D