Novel self-assembly nano OSA starch micelles controlled by protonation in aqueous media

Yang Li; Qunyu Gao

doi:10.1016/j.carbpol.2022.120146

Novel self-assembly nano OSA starch micelles controlled by protonation in aqueous media

Carbohydr Polym. 2023 Jan 1:299:120146. doi: 10.1016/j.carbpol.2022.120146. Epub 2022 Sep 29.

Authors

Yang Li¹, Qunyu Gao²

Affiliations

¹ Carbohydrate Laboratory, School of Food Science and Engineering, South China University of Technology, 381 Wushan Rd., Tianhe District, Guangzhou 510640, PR China.
² Carbohydrate Laboratory, School of Food Science and Engineering, South China University of Technology, 381 Wushan Rd., Tianhe District, Guangzhou 510640, PR China. Electronic address: qygao@scut.edu.cn.

PMID: 36876775
DOI: 10.1016/j.carbpol.2022.120146

Abstract

A new micellization method was applied to produce the nano octenyl succinic anhydride (OSA) modified starch micelles with controllable size. The underlying mechanism was explored by using Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), dynamic light scattering (DLS), zeta-potential, surface tension, fluorescence spectra and transmission electron microscope (TEM). Due to the new starch modification method, the electrostatic repulsion between the deprotonation carboxyl groups prevented the aggregation of starch chains. With the progress of protonation, the weaken electrostatic repulsion and enhanced hydrophobic interaction driven the self-assembly of micelles. The size of micelles increased gradually with the increase of the protonation degree (PD) and concentration of OSA starch. However, a V-shaped trends were observed in the size as the increase of substitution of degree (DS). Curcuma loading test indicated that micelles had good encapsulated capability and the maximum value was 52.2 μg/mg. The understanding of the self-assembly behavior of OSA starch micelles can facilitate and improve the starch-based carrier designs used to synthesis complex and smart micelle delivery system with good biocompatibility.

Keywords: Curcumin; Molecular interactions; OSA starch; PubChem CID: 10340, Sodium carbonate; PubChem CID: 14798, Sodium hydroxide; PubChem CID: 24243, Sodium phosphate tribasic; PubChem CID: 31423, Pyrene; PubChem CID: 5362721, Octenyl succinic anhydride; PubChem CID: 6344, Dichloromethane; PubChem CID: 679, Dimethyl sulfoxide; PubChem CID: 71502, Trifluoroacetic acid-d(1); PubChem CID: 75151, DMSO-d(6); PubChem CID: 969516, Curcumin; Self-assembly; Size; Starch micelle.