A review on the role of long non-coding RNA prostate androgen-regulated transcript 1 (PART1) in the etiology of different disorders

Soudeh Ghafouri-Fard; Atefeh Harsij; Bashdar Mahmud Hussen; Snur Rasool Abdullah; Aria Baniahmad; Mohammad Taheri; Guive Sharifi

doi:10.3389/fcell.2023.1124615

A review on the role of long non-coding RNA prostate androgen-regulated transcript 1 (PART1) in the etiology of different disorders

Front Cell Dev Biol. 2023 Feb 15:11:1124615. doi: 10.3389/fcell.2023.1124615. eCollection 2023.

Authors

Soudeh Ghafouri-Fard¹, Atefeh Harsij², Bashdar Mahmud Hussen³, Snur Rasool Abdullah⁴, Aria Baniahmad⁵, Mohammad Taheri^{6

7}, Guive Sharifi⁷

Affiliations

¹ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
⁴ Medical Laboratory Science, Lebanese French University, Erbil, Kurdistan Region, Iraq.
⁵ Institute of Human Genetics, Jena University Hospital, Jena, Germany.
⁶ Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁷ Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

LncRNA prostate androgen-regulated transcript 1 (PART1) is an important lncRNA in the carcinogenesis whose role has been firstly unraveled in prostate cancer. Expression of this lncRNA is activated by androgen in prostate cancer cells. In addition, this lncRNA has a role in the pathogenesis intervertebral disc degeneration, myocardial ischemia-reperfusion injury, osteoarthritis, osteoporosis and Parkinson's disease. Diagnostic role of PART1 has been assessed in some types of cancers. Moreover, dysregulation of PART1 expression is regarded as a prognostic factor in a variety of cancers. The current review provides a concise but comprehensive summary of the role of PART1 in different cancers and non-malignant disorders.

Keywords: PART1; biomarker; cancer; diagnsotic marker; lncRNA.

Publication types

Review