Cellular mechanisms linking to outdoor and indoor air pollution damage during pregnancy

Front Endocrinol (Lausanne). 2023 Feb 15:14:1084986. doi: 10.3389/fendo.2023.1084986. eCollection 2023.

Abstract

Pregnancies are a critical window period for environmental influences over the mother and the offspring. There is a growing body of evidence associating indoor and outdoor air pollution exposure to adverse pregnancy outcomes such as preterm birth and hypertensive disorders of pregnancy. Particulate matter (PM) could trigger oxi-inflammation and could also reach the placenta leading to placental damage with fetal consequences. The combination of strategies such as risk assessment, advise about risks of environmental exposures to pregnant women, together with nutritional strategies and digital solutions to monitor air quality can be effective in mitigating the effects of air pollution during pregnancy.

Keywords: PM2.5; cell damage; exposome; indoor - outdoor pollution; mitigation strategies; pregnancy.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Air Pollution*
  • Air Pollution, Indoor*
  • Environmental Exposure
  • Female
  • Humans
  • Infant, Newborn
  • Placenta
  • Pregnancy
  • Premature Birth*

Grants and funding

FONDECYT 1221362 to JG (Universidad San Sebastián, Chile). CONICYT, PAI Convocatoria Nacional Subvención a Instalación en la Academia, Convocatoria Año 2019, Folio N°PAI77190060 to DC. PAI Convocatoria Nacional Subvención a Instalación en la Academia, Convocatoria Año 2021, Folio N°SA77210087 to IC-W.