Oxidative stress in cerebrovascular disease and associated diseases

Vijay Kumar; Kausik Bishayee; Soochul Park; Unjoo Lee; Jaebong Kim

doi:10.3389/fendo.2023.1124419

Oxidative stress in cerebrovascular disease and associated diseases

Front Endocrinol (Lausanne). 2023 Feb 17:14:1124419. doi: 10.3389/fendo.2023.1124419. eCollection 2023.

Authors

Vijay Kumar¹, Kausik Bishayee², Soochul Park³, Unjoo Lee⁴, Jaebong Kim¹

Affiliations

¹ Department of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon, Republic of Korea.
² Biomedical Science Core-Facility, Soonchunhyang Institute of Medi-Bio Science, Soonchunhyang University, Cheonan, Republic of Korea.
³ Department of Biological Sciences, Sookmyung Women's University, Seoul, Republic of Korea.
⁴ Department of Electrical Engineering, Hallym University, Chuncheon, Republic of Korea.

Abstract

Cellular aging is the most severe risk factor for neurodegenerative disease. Simultaneously, oxidative stress (OS) is a critical factor in the aging process, resulting from an imbalance between reactive oxygen and nitrogen species and the antioxidant defense system. Emerging evidence indicates that OS is a common cause of several age-related brain pathologies, including cerebrovascular diseases. Elevated OS disrupts endothelial functional ability by diminishing the bioavailability of nitric oxide (a vascular dilator), induces atherosclerosis, and impairs vasculature, which are all common characteristics of cerebrovascular disease. In this review, we summarize evidence supporting an active role of OS in cerebrovascular disease progression, focusing primarily on stroke pathogenesis. We briefly discuss hypertension, diabetes, heart disease, and genetic factors that are often linked to OS and are considered associated factors influencing stroke pathology. Finally, we discuss the current pharmaceutics/therapeutics available for treating several cerebrovascular diseases.

Keywords: hypertension; neurodegeneration; oxidative stress; risk factors; stroke.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cerebrovascular Disorders*
Humans
Hypertension*
Neurodegenerative Diseases*
Oxidative Stress
Stroke*

Grants and funding

This study was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology of Korea (2016R1D1A1B02008770, 2018M3C7A1056285, 2021R1A4A1027355, 2021M3H9A1097557, and 2022R1I1A3066646).