Association between urinary nickel with obesity status in adults: A cross-sectional study

Front Public Health. 2023 Feb 17:11:1094062. doi: 10.3389/fpubh.2023.1094062. eCollection 2023.

Abstract

Objectives: The prevalence of obesity is on the rise and is connected to numerous factors. However, the relationship between obesity and nickel has never been investigated. Our study aimed to explore the association between urinary nickel and obesity Status in adults.

Methods: From the 2017-2018 National Health and Nutrition Examination Surveys (NHANES), 1,705 participants ≥18 years of age were enrolled. To explore further the relationship among urinary nickel, body mass index (BMI), and waist circumference(WC), Weighted multivariate linear regression analyses and further subgroup analyzes were conducted.

Results: Urinary nickel does not correlate with BMI level but positively correlates with WC. In the subgroup analyzed according to sex, Urinary nickel has a positive correlation with BMI and WC in males but has a negative correlation in females. Secondary stratification analysis according to sex and race, Urinary nickel positively correlates with BMI in White males. It also positively correlates with WC in both White and Black males.

Conclusions: A correlation was found between urinary nickel levels and BMI and WC in adult males. Adult men, especially those already obese, may need to reduce nickel exposure.

Keywords: NHANES; body mass index; obesity; urinary nickel; waist circumference.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Nickel* / urine
  • Nutrition Surveys
  • Obesity* / epidemiology
  • Obesity* / urine

Substances

  • Nickel

Grants and funding

This study was funded by the National Natural Science Foundation of China (No. 82104759) and the Natural Science Foundation of Guangdong Provincial (No. 2019A1515110108).