The burden of diabetes on the soft tissue seal surrounding the dental implants

Zhanwei Zhang; Chonghao Ji; Daobin Wang; Maoshan Wang; Dawei Song; Xin Xu; Dongjiao Zhang

doi:10.3389/fphys.2023.1136973

The burden of diabetes on the soft tissue seal surrounding the dental implants

Front Physiol. 2023 Feb 16:14:1136973. doi: 10.3389/fphys.2023.1136973. eCollection 2023.

Authors

Zhanwei Zhang¹, Chonghao Ji¹, Daobin Wang², Maoshan Wang¹, Dawei Song³, Xin Xu¹, Dongjiao Zhang¹

Affiliations

¹ Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral, Shandong University , Jinan, China.
² Taian Municipal Hospital, Tai'an, China.
³ School of Stomatology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China.

Abstract

Soft tissue seal around implant prostheses is considered the primary barrier against adverse external stimuli and is a critical factor in maintaining dental implants' stability. Soft tissue seal is formed mainly by the adhesion of epithelial tissue and fibrous connective tissue to the transmembrane portion of the implant. Type 2 diabetes mellitus (T2DM) is one of the risk factors for peri-implant inflammation, and peri-implant disease may be triggered by dysfunction of the soft tissue barrier around dental implants. This is increasingly considered a promising target for disease treatment and management. However, many studies have demonstrated that pathogenic bacterial infestation, gingival immune inflammation, overactive matrix metalloproteinases (MMPs), impaired wound healing processes and excessive oxidative stress may trigger poor peri-implant soft tissue sealing, which may be more severe in the T2DM state. This article reviews the structure of peri-implant soft tissue seal, peri-implant disease and treatment, and moderating mechanisms of impaired soft tissue seal around implants due to T2DM to inform the development of treatment strategies for dental implants in patients with dental defects.

Keywords: dental implants; diabetes; extracellular matrix; mucous integration; peri-implantitis; soft tissue sealing.

Publication types

Review

Grants and funding

This research was funded by the National Natural Science Foundation of China, grant no. 82071148; the Natural Science Foundation of Shandong Province, grant no. ZR2021MH092; and the Natural Science Foundation of Jiangsu Province (Suzhou Research Institute of Shandong University), grant no. BK20210111.