Prognostic significance of the angiopoietin-2 for early prediction of septic shock in severe sepsis patients

Luu Thi Thanh Duyen; Bui Van Manh; Tran Thi Phuong Thao; Le Van Khanh; Bui Ngoc Linh Trang; Ngo Truong Giang; Ha Van Quang; Nguyen Thanh Viet; Ngo Thu Hang; Can Van Mao; Nguyen Linh Toan; Hoang Van Tong

doi:10.2144/fsoa-2022-0077

Prognostic significance of the angiopoietin-2 for early prediction of septic shock in severe sepsis patients

Future Sci OA. 2023 Jan 27;8(10):FSO825. doi: 10.2144/fsoa-2022-0077. eCollection 2022 Dec.

Authors

Affiliations

¹ Surgical Intensive Care Unit, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam.
² Surgical Intensive Care Unit, Viet Tiep Hospital, Hai Phong, Vietnam.
³ Institute of Biomedicine & Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam.
⁴ Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam.

Abstract

Aim: The current study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis.

Methods: Angiopoietin-1 and -2 levels were quantified in plasma from 105 patients with severe sepsis by ELISA.

Results: Angiopoietin-2 levels elevated according to the severity of sepsis progression. Angiopoietin-2 levels were correlated with mean arterial pressure and platelets counts, total bilirubin, creatinine, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately discriminated for sepsis with an AUC = 0.97 and septic shock from severe sepsis patients (AUC = 0.778).

Conclusion: Plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic shock.

Keywords: angiopoietin-1; angiopoietin-2; biomarker; sepsis; septic shock.

Plain language summary

The study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis in plasma from 105 patients with severe sepsis by ELISA. The results showed that angiopoietin-2 levels elevated according to the severity of sepsis progression and were correlated with important clinical parameters such as mean arterial pressure and platelets counts, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately discriminated for sepsis and septic shock. Thus, plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic shock.