The progress in our understanding of CIN in breast cancer research

Yu-Yang Liao; Wen-Ming Cao

doi:10.3389/fonc.2023.1067735

The progress in our understanding of CIN in breast cancer research

Front Oncol. 2023 Feb 16:13:1067735. doi: 10.3389/fonc.2023.1067735. eCollection 2023.

Authors

Yu-Yang Liao^{1

2}, Wen-Ming Cao²

Affiliations

¹ Wenzhou Medical University, Wenzhou, China.
² Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, China.

Abstract

Chromosomal instability (CIN) is an important marker of cancer, which is closely related to tumorigenesis, disease progression, treatment efficacy, and patient prognosis. However, due to the limitations of the currently available detection methods, its exact clinical significance remains unknown. Previous studies have demonstrated that 89% of invasive breast cancer cases possess CIN, suggesting that it has potential application in breast cancer diagnosis and treatment. In this review, we describe the two main types of CIN and discuss the associated detection methods. Subsequently, we highlight the impact of CIN in breast cancer development and progression and describe how it can influence treatment and prognosis. The goal of this review is to provide a reference on its mechanism for researchers and clinicians.

Keywords: aneuploidy; breast cancer; chromosomal instability; drug resistance; genetic instability; metastasis; prognosis; treatment.

Publication types

Review

Grants and funding

This work was funded by grants from the Key Research-Development Program of Zhejiang Province (grant numbers: 2019C04001), the Natural Science Foundation of Zhejiang Province, China (grant number: LY21H160005).