Controlled-release of apatinib for targeted inhibition of osteosarcoma by supramolecular nanovalve-modified mesoporous silica

Xinglong Wang; Gongke Li; Ke Li; Yu Shi; Wenzheng Lin; Chun Pan; Dandan Li; Hao Chen; Jianwei Du; Huihui Wang

doi:10.3389/fbioe.2023.1135655

Controlled-release of apatinib for targeted inhibition of osteosarcoma by supramolecular nanovalve-modified mesoporous silica

Front Bioeng Biotechnol. 2023 Feb 16:11:1135655. doi: 10.3389/fbioe.2023.1135655. eCollection 2023.

Authors

Xinglong Wang¹, Gongke Li², Ke Li¹, Yu Shi¹, Wenzheng Lin¹, Chun Pan¹, Dandan Li¹, Hao Chen¹, Jianwei Du¹, Huihui Wang¹

Affiliations

¹ Department of Orthopedics, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China.
² Department of Critical Care Medicine, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China.

Abstract

Targeted delivery of antitumor drugs has been recognized as a promising therapeutic modality to improve treatment efficacy, reduce the toxic side effects and inhibit tumor recurrence. In this study, based on the high biocompatibility, large specific surface area, and easy surface modification of small-sized hollow mesoporous silica nanoparticles β-cyclodextrin (β-CD)-benzimidazole (BM) supramolecular nanovalve, together with bone-targeted alendronate sodium (ALN) were constructed on the surface of small-sized HMSNs. The drug loading capacity and efficiency of apatinib (Apa) in HMSNs/BM-Apa-CD-PEG-ALN (HACA) were 65% and 25%, respectively. More importantly, HACA nanoparticles can release the antitumor drug Apa efficiently compared with non-targeted HMSNs nanoparticles in the acidic microenvironment of the tumor. In vitro studies showed that HACA nanoparticles exhibited the most potent cytotoxicity in osteosarcoma cells (143B cells) and significantly reduced cell proliferation, migration and invasion. Therefore, the drug-efficient release of antitumor effect of HACA nanoparticles is a promising way to treat osteosarcoma.

Keywords: APA; AlN; Cd; HMSNs; supramolecular nanovalves.

Grants and funding

This study was supported by National Natural Science Foundation of China (8217090346, 81802132), Natural Science Foundation of Jiangsu Province (SBK2021022619), Natural Science Fund for Colleges and Universities in Jiangsu Province (21KJB320009, 21KJB310017).