The E3 ubiquitin ligases regulate inflammation in cardiovascular diseases

Xiao Chen; Jia Ma; Zhi-Wei Wang; Zhiting Wang

doi:10.1016/j.semcdb.2023.02.008

The E3 ubiquitin ligases regulate inflammation in cardiovascular diseases

Semin Cell Dev Biol. 2024 Feb 15;154(Pt C):167-174. doi: 10.1016/j.semcdb.2023.02.008. Epub 2023 Mar 3.

Authors

Xiao Chen¹, Jia Ma², Zhi-Wei Wang³, Zhiting Wang⁴

Affiliations

¹ Department of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
² Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical College, Bengbu, Anhui, 233030, China.
³ The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address: zhiweichina@126.com.
⁴ Department of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address: wangzhiting@wmu.edu.cn.

PMID: 36872193
DOI: 10.1016/j.semcdb.2023.02.008

Abstract

Accumulating evidence has illustrated that the E3 ubiquitin ligases critically participate in the development and progression of cardiovascular diseases. Dysregulation of E3 ubiquitin ligases exacerbates cardiovascular diseases. Blockade or activation of E3 ubiquitin ligases mitigates cardiovascular performance. Therefore, in this review, we mainly introduced the critical role and underlying molecular mechanisms of E3 ubiquitin ligase NEDD4 family in governing the initiation and progression of cardiovascular diseases, including ITCH, WWP1, WWP2, Smurf1, Smurf2, Nedd4-1 and Nedd4-2. Moreover, the functions and molecular insights of other E3 ubiquitin ligases, such as F-box proteins, in cardiovascular disease development and malignant progression are described. Furthermore, we illustrate several compounds that alter the expression of E3 ubiquitin ligases to alleviate cardiovascular diseases. Therefore, modulation of E3 ubiquitin ligases could be a novel and promising strategy for improvement of therapeutic efficacy of deteriorative cardiovascular diseases.

Keywords: Cardiovascular disease; Degradation; E3 ligases, Inflammation; Heart.

Publication types

Review