Massive Trauma and Resuscitation Strategies

Carter M Galbraith; Brant M Wagener; Athanasios Chalkias; Shahla Siddiqui; David J Douin

doi:10.1016/j.anclin.2022.10.008

Massive Trauma and Resuscitation Strategies

Anesthesiol Clin. 2023 Mar;41(1):283-301. doi: 10.1016/j.anclin.2022.10.008.

Authors

Carter M Galbraith¹, Brant M Wagener², Athanasios Chalkias³, Shahla Siddiqui⁴, David J Douin⁵

Affiliations

¹ Division of Critical Care Medicine, Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, 619 19th Street South, JT 845, Birmingham, AL 35249, USA.
² Division of Critical Care Medicine, University of Alabama at Birmingham, 901 19th Street South, PBMR 302, Birmingham, AL 35294, USA; Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, 901 19th Street South, PBMR 302, Birmingham, AL 35294, USA.
³ Department of Anesthesiology, University of Thessaly, Biopolis, Larisa 41500, Greece; Outcomes Research Consortium, Cleveland, OH 44195, USA.
⁴ Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address: ssiddiq4@bidmc.harvard.edu.
⁵ Department of Anesthesiology, University of Colorado School of Medicine, 12401 East 17th Avenue, 7th Floor, Aurora, CO 80045, USA. Electronic address: david.douin@cuanschutz.edu.

Abstract

Massive trauma remains the leading cause of mortality among people aged younger than 45 years. In this review, we discuss the initial care and diagnosis of trauma patients followed by a comparison of resuscitation strategies. We discuss various strategies including use of whole blood and component therapy, examine viscoelastic techniques for management of coagulopathy, and consider the benefits and limitations of the resuscitation strategies and consider a series of questions that will be important for researchers to answer to provide the best and most cost-effective therapy for severely injured patients.

Keywords: Coagulopathy; Component therapy; Resuscitation; Trauma; Viscoelastic technique; Whole blood.

Massive Trauma and Resuscitation Strategies

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