Cancer-targeted fucoidan‑iron oxide nanoparticles for synergistic chemotherapy/chemodynamic theranostics through amplification of P-selectin and oxidative stress

Thi-Luu Ho; Chinmaya Mutalik; Lekshmi Rethi; Huynh-Ngoc Truc Nguyen; Pei-Ru Jheng; Chin-Chean Wong; Tzu-Sen Yang; Thi Thuy Nguyen; Bradley W Mansel; Chen-An Wang; Er-Yuan Chuang

doi:10.1016/j.ijbiomac.2023.123821

Cancer-targeted fucoidan‑iron oxide nanoparticles for synergistic chemotherapy/chemodynamic theranostics through amplification of P-selectin and oxidative stress

Int J Biol Macromol. 2023 Apr 30:235:123821. doi: 10.1016/j.ijbiomac.2023.123821. Epub 2023 Mar 2.

Authors

Affiliations

¹ Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan; International Ph.D. Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
² International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
³ Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
⁴ Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
⁵ Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan; Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan; Research Center of Biomedical Devices, Taipei Medical University, Taipei 11031, Taiwan; International Ph.D. Program for Cell Therapy and Regenerative Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
⁶ Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
⁷ International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan; Department of Oncology, Hue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam.
⁸ National Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan.
⁹ Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan; Cell Physiology and Molecular Image Research Center, Taipei Medical University-Wan Fang Hospital, Taipei 11696, Taiwan. Electronic address: eychuang@tmu.edu.tw.

PMID: 36870633
DOI: 10.1016/j.ijbiomac.2023.123821

Abstract

A combination of chemotherapy and chemodynamic therapy (CDT) is being developed to improve the theranostic efficacy and biological safety of current therapies. However, most CDT agents are restricted due to complex issues such as multiple components, low colloidal stability, carrier-associated toxicity, insufficient reactive oxygen species generation, and poor targeting efficacy. To overcome these problems, a novel nanoplatform composed of fucoidan (Fu) and iron oxide (IO) nanoparticles (NPs) was developed to achieve chemotherapy combined with CDT synergistic treatment with a facile self-assembling manner, and the NPs were made up of Fu and IO, in which the Fu was not only used as a potential chemotherapeutic but was also designed to stabilize the IO and target P-selectin-overexpressing lung cancer cells, thereby producing oxidative stress and thus synergizing the CDT efficacy. The Fu-IO NPs exhibited a suitable diameter below 300 nm, which favored their cellular uptake by cancer cells. Microscopic and MRI data confirmed the lung cancer cellular uptake of the NPs due to active Fu targeting. Moreover, Fu-IO NPs induced efficient apoptosis of lung cancer cells, and thus offer significant anti-cancer functions by potential chemotherapeutic-CDT.

Keywords: Amplification of P-selectin and oxidative stress; Cancer-targeted fucoidan‑iron oxide nanoparticles; Synergistic chemotherapy/chemodynamic theranostics.

MeSH terms

Cell Line, Tumor
Humans
Lung Neoplasms* / drug therapy
Magnetic Iron Oxide Nanoparticles
Nanoparticles* / therapeutic use
Neoplasms* / drug therapy
Oxidative Stress
P-Selectin
Precision Medicine
Theranostic Nanomedicine

Substances

fucoidan
P-Selectin