Review: The application of corticosteroids in cryptococcal meningitis

Junyu Liu; Jia Liu; Lu Yang; Xiaofeng Xu; Qin Bang-E; Ying Jiang; Fuhua Peng

doi:10.1016/j.mycmed.2023.101364

Review: The application of corticosteroids in cryptococcal meningitis

J Mycol Med. 2023 May;33(2):101364. doi: 10.1016/j.mycmed.2023.101364. Epub 2023 Feb 24.

Authors

Junyu Liu¹, Jia Liu¹, Lu Yang¹, Xiaofeng Xu¹, Qin Bang-E¹, Ying Jiang², Fuhua Peng³

Affiliations

¹ Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, PR China.
² Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, PR China. Electronic address: jiangy9@mail.sysu.edu.cn.
³ Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, PR China. Electronic address: pengfh@mail.sysu.edu.cn.

PMID: 36870302
DOI: 10.1016/j.mycmed.2023.101364

Abstract

Cryptococcal meningitis (CM) is a serious disease with high morbidity and mortality. Although the patients who received corticosteroids were at high risk of having CM, corticosteroids also have been used as an adjunct to antifungal drugs for treating people with CM in some situations (such as immune reconstitution inflammatory syndrome, cerebral cyptococcoma, et al.). Here, we summarize the current knowledge on the application of the corticosteroids in CM, aiming to help clinicians to reasonably use corticosteroids in patients with CM.

Keywords: Complication; Corticosteroids; Cryptococcal meningitis; Therapy; Underlying diseases.

Publication types

Review

MeSH terms

AIDS-Related Opportunistic Infections* / drug therapy
Adrenal Cortex Hormones / therapeutic use
Antifungal Agents / therapeutic use
HIV Infections* / drug therapy
Humans
Meningitis, Cryptococcal* / drug therapy

Substances

Antifungal Agents
Adrenal Cortex Hormones