Maresin1 can be a potential therapeutic target for nerve injury

Xichen Wang; Benson O A Botchway; Yong Zhang; Min Huang; Xuehong Liu

doi:10.1016/j.biopha.2023.114466

Maresin1 can be a potential therapeutic target for nerve injury

Biomed Pharmacother. 2023 May:161:114466. doi: 10.1016/j.biopha.2023.114466. Epub 2023 Mar 2.

Authors

Xichen Wang¹, Benson O A Botchway², Yong Zhang¹, Min Huang¹, Xuehong Liu³

Affiliations

¹ Department of Histology and Embryology, School of Medicine, Shaoxing University, Zhejiang, China.
² Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China; Bupa Cromwell Hospital, London, UK.
³ Department of Histology and Embryology, School of Medicine, Shaoxing University, Zhejiang, China. Electronic address: liuxueh6588@126.com.

PMID: 36870281
DOI: 10.1016/j.biopha.2023.114466

Abstract

Nerve injury significantly affects human motor and sensory function due to destruction of the integrity of nerve structure. In the wake of nerve injury, glial cells are activated, and synaptic integrity is destroyed, causing inflammation and pain hypersensitivity. Maresin1, an omega-3 fatty acid, is a derivative of docosahexaenoic acid. It has showed beneficial effects in several animal models of central and peripheral nerve injuries. In this review, we summarize the anti-inflammatory, neuroprotective and pain hypersensitivity effects of maresin1 in nerve injury and provide a theoretical basis for the clinical treatment of nerve injury using maresin1.

Keywords: Inflammation; Macrophages; Maresin1; Nerve injury; Neuronal protection; Therapeutic target.

Publication types

Review

MeSH terms

Animals
Disease Models, Animal
Docosahexaenoic Acids / pharmacology
Docosahexaenoic Acids / therapeutic use
Humans
Inflammation / drug therapy
Neuroglia*
Pain / drug therapy
Peripheral Nerve Injuries* / drug therapy

Substances

Docosahexaenoic Acids