Global burden of common cancers attributable to metabolic risks from 1990 to 2019

Qing-Qing Xing; Jing-Mao Li; Zhi-Jian Chen; Xiao-Yun Lin; Yan-Ying You; Mei-Zhu Hong; Shangeng Weng; Jin-Shui Pan

doi:10.1016/j.medj.2023.02.002

Global burden of common cancers attributable to metabolic risks from 1990 to 2019

Med. 2023 Mar 10;4(3):168-181.e3. doi: 10.1016/j.medj.2023.02.002. Epub 2023 Mar 2.

Authors

Qing-Qing Xing¹, Jing-Mao Li², Zhi-Jian Chen¹, Xiao-Yun Lin¹, Yan-Ying You¹, Mei-Zhu Hong³, Shangeng Weng⁴, Jin-Shui Pan⁵

Affiliations

¹ Department of Hepatology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China; Hepatology Research Institute, Fujian Medical University, Fuzhou, Fujian 350005, China; Fujian Clinical Research Center for Liver and Intestinal Diseases, Fuzhou, Fujian 350005, China.
² Department of Statistics, School of Economics, Xiamen University, Xiamen, Fujian 361000, China.
³ Department of Traditional Chinese Medicine, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China. Electronic address: 546777397@qq.com.
⁴ Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China. Electronic address: shangeng@sina.com.
⁵ Department of Hepatology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China; Hepatology Research Institute, Fujian Medical University, Fuzhou, Fujian 350005, China; Fujian Clinical Research Center for Liver and Intestinal Diseases, Fuzhou, Fujian 350005, China. Electronic address: j.s.pan76@fjmu.edu.cn.

PMID: 36868237
DOI: 10.1016/j.medj.2023.02.002

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is usually accompanied by metabolic syndrome, which is associated with increased risk of cancer. To inform a tailored cancer screen in patients at higher risks, we estimated the global burden of cancer attributable to metabolic risks.

Methods: Data of common metabolism-related neoplasms (MRNs) were derived from the Global Burden of Disease (GBD) 2019 database. Age-standardized, disability-adjusted life year (DALY) rates and death rates of patients with MRNs were extracted from the GBD 2019 database and stratified by metabolic risk, sex, age, and level of socio-demographic index (SDI). The annual percentage changes of age-standardized DALYs and death rates were calculated.

Findings: Metabolic risks, consisting of high body mass index and fasting plasma glucose, contributed substantially to the burden of neoplasms, including colorectal cancer (CRC), tracheal, bronchus, and lung cancer (TBLC), etc. Globally, in 2019, there was an estimated age-standardized DALY rate (ASDR) of 234 (95% confidence interval [CI] 124-376) per 100,000 person years for neoplasms attributable to metabolic risks. ASDRs of MRNs were higher for CRC, TBLC, men, patients aged ≥50 years, and patients with high or high-middle SDI.

Conclusions: The findings of this study further underpin the correlation between NAFLD and intrahepatic and extrahepatic cancers and highlight the possibility of tailored cancer screening for the NAFLD population at higher risks.

Funding: This work was supported by the National Natural Science Foundation of China and Natural Science Foundation of Fujian Province of China.

Keywords: Translation to population health; diabetes mellitus; metabolic syndrome; neoplasms; non-alcoholic fatty liver disease; obesity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Disability-Adjusted Life Years
Global Burden of Disease
Humans
Lung Neoplasms*
Male
Non-alcoholic Fatty Liver Disease*
Quality-Adjusted Life Years