Hb Santa Juana (β 108(G10) Asn > Ser): a low oxygen affinity hemoglobin variant in a family of Bosnian background

N P Wildenberg; C Rossi; A E Kulozik; J B Kunz

doi:10.1080/16078454.2023.2184120

Hb Santa Juana (β 108(G10) Asn > Ser): a low oxygen affinity hemoglobin variant in a family of Bosnian background

Hematology. 2023 Dec;28(1):2184120. doi: 10.1080/16078454.2023.2184120.

Authors

N P Wildenberg^{1

2}, C Rossi^{1

2}, A E Kulozik^{1

2}, J B Kunz^{1

2}

Affiliations

¹ Department of Pediatric Oncology, Hematology, and Immunology, University of Heidelberg, Heidelberg, Germany.
² Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

PMID: 36867085
DOI: 10.1080/16078454.2023.2184120

Abstract

We present a family that carries the β-hemoglobin variant Hb Santa Juana (HBB:c.326A>G, β 108(G10) Asn>Ser), also known as Hb Serres, in three generations. All affected family members had an anomal hemoglobin fraction as detected by HPLC but normal blood count without evidence of anemia or hemolysis. Oxygen affinity (p₅₀ (O₂) = 31.9-40.4 mmHg) was decreased in all probands, compared to 24.9-28.1 mmHg in unaffected individuals. Clinical symptoms likely related to the hemoglobin variant were cyanosis during anaesthesia, while other complaints such as shortness of breath or dizziness were less clearly linked with the hemoglobin variant.

Keywords: Hemoglobin; hemoglobinopathy; oxygen affinity.

MeSH terms

Chromatography, High Pressure Liquid
Cyanosis*
Dyspnea
Hemoglobins*
Humans
Oxygen

Substances

Hemoglobins
Oxygen