Modulation of neuronal excitability by binge alcohol drinking

Pablo Gimenez-Gomez; Timmy Le; Gilles E Martin

doi:10.3389/fnmol.2023.1098211

Modulation of neuronal excitability by binge alcohol drinking

Front Mol Neurosci. 2023 Feb 14:16:1098211. doi: 10.3389/fnmol.2023.1098211. eCollection 2023.

Authors

Pablo Gimenez-Gomez^{1

2}, Timmy Le^{1

2

3}, Gilles E Martin^{1

2}

Affiliations

¹ Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
² The Brudnick Neuropsychiatric Research Institute, Worcester, MA, United States.
³ Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, United States.

Abstract

Drug use poses a serious threat to health systems throughout the world. The number of consumers rises every year being alcohol the drug of abuse most consumed causing 3 million deaths (5.3% of all deaths) worldwide and 132.6 million disability-adjusted life years. In this review, we present an up-to-date summary about what is known regarding the global impact of binge alcohol drinking on brains and how it affects the development of cognitive functions, as well as the various preclinical models used to probe its effects on the neurobiology of the brain. This will be followed by a detailed report on the state of our current knowledge of the molecular and cellular mechanisms underlying the effects of binge drinking on neuronal excitability and synaptic plasticity, with an emphasis on brain regions of the meso-cortico limbic neurocircuitry.

Keywords: alcohol; binge alcohol drinking; ion channel; neuroadaptation; neuronal excitability.

Publication types

Review

Abstract

Publication types

Grants and funding