Neuroplasticity of pain processing and motor control in CAI patients: A UK Biobank study with clinical validation

Yiran Wang; Qianru Li; Xiao'ao Xue; Xiaoyun Xu; Weichu Tao; Sixu Liu; Yunyi Li; He Wang; Yinghui Hua

doi:10.3389/fnmol.2023.1096930

Neuroplasticity of pain processing and motor control in CAI patients: A UK Biobank study with clinical validation

Front Mol Neurosci. 2023 Feb 14:16:1096930. doi: 10.3389/fnmol.2023.1096930. eCollection 2023.

Authors

Yiran Wang¹, Qianru Li¹, Xiao'ao Xue¹, Xiaoyun Xu², Weichu Tao², Sixu Liu³, Yunyi Li³, He Wang^{4

5

6}, Yinghui Hua^{1

7}

Affiliations

¹ Department of Sports Medicine, Fudan University, Shanghai, China.
² School of Exercise and Health, Shanghai University of Sport, Shanghai, China.
³ Department of Biomedical Engineering, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
⁴ Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
⁵ Human Phenome Institute, Fudan University, Shanghai, China.
⁶ Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Ministry of Education, Fudan University, Shanghai, China.
⁷ Yiwu Research Institute of Fudan University, Yiwu, China.

Abstract

Background: Pain plays an important role in chronic ankle instability (CAI), and prolonged pain may be associated with ankle dysfunction and abnormal neuroplasticity.

Purpose: To investigate the differences in resting-state functional connectivity among the pain-related brain regions and the ankle motor-related brain regions between healthy controls and patients with CAI, and explore the relationship between patients' motor function and pain.

Study design: A cross-database, cross-sectional study.

Methods: This study included a UK Biobank dataset of 28 patients with ankle pain and 109 healthy controls and a validation dataset of 15 patients with CAI and 15 healthy controls. All participants underwent resting-state functional magnetic resonance imaging scanning, and the functional connectivity (FC) among the pain-related brain regions and the ankle motor-related brain regions were calculated and compared between groups. The correlations between the potentially different functional connectivity and the clinical questionnaires were also explored in patients with CAI.

Results: The functional connection between the cingulate motor area and insula significantly differed between groups in both the UK Biobank (p = 0.005) and clinical validation dataset (p = 0.049), which was also significantly correlated with Tegner scores (r = 0.532, p = 0.041) in patients with CAI.

Conclusion: A reduced functional connection between the cingulate motor area and the insula was present in patients with CAI, which was also directly correlated with reduction in the level of patient physical activity.

Keywords: ankle injuries; central nervous system; functional connection; functional magnetic resonance imaging; pain.

Grants and funding

This work was supported by the National Natural Science Foundation of China (Nos. 81871823, 81971583, 81671652, and 8207090113), National Key R&D Program of China (No. 2018YFC1312900), Shanghai Natural Science Foundation (No. 20ZR1406400), Science and Technology Commission of Shanghai Municipality (No. 18JC1410403), and Shanghai Municipal Science and Technology Major Project (Nos. 2017SHZDZX01 and 2018SHZDZX01).