Studies on the role of non-coding RNAs in controlling the activity of T cells in asthma

Albert Sufianov; Marina Bessonova; Sema Begliarzade; Valentin Kudriashov; Andrei Danilov; Tatiana Ilyasova; Wang Yaolou; Radmila Nafikova; Ozal Beylerli

doi:10.1016/j.ncrna.2023.02.004

Studies on the role of non-coding RNAs in controlling the activity of T cells in asthma

Noncoding RNA Res. 2023 Feb 15;8(2):211-217. doi: 10.1016/j.ncrna.2023.02.004. eCollection 2023 Jun.

Authors

Albert Sufianov^{1

2}, Marina Bessonova³, Sema Begliarzade⁴, Valentin Kudriashov⁵, Andrei Danilov⁶, Tatiana Ilyasova⁷, Wang Yaolou⁸, Radmila Nafikova⁹, Ozal Beylerli¹

Affiliations

¹ Educational and Scientific Institute of Neurosurgery, Рeoples' Friendship University of Russia (RUDN University), Moscow, Russia.
² Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
³ Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk, Russia.
⁴ Republican Clinical Perinatal Center, Ufa, Republic of Bashkortostan, 450106, Russia.
⁵ Gastric Cancer Center, West China Hospital of Sichuan University, China.
⁶ Department of Clinical Pharmacology, Smolensk State Medical University, Smolensk, Russia.
⁷ Department of Internal Diseases, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 450008, Russia.
⁸ Harbin Medical University, 157 Baojian Rd, Nangang, Harbin, Heilongjiang, 150088, China.
⁹ Department of Pulmonary and Critical care, Northwestern University, Chicago, United States.

Abstract

Bronchial asthma, commonly known as asthma, is a chronic inflammatory disease characterized by airway inflammation, increased responsiveness and changes in airway structure. T cells, particularly T helper cells, play a crucial role in the disease. Non-coding RNAs, which are RNAs that do not code for proteins, mainly include microRNAs, long non-coding RNAs, and circular RNAs, play a role in regulating various biological processes. Studies have shown that non-coding RNAs have an important role in the activation and transformation of T cells and other biological processes in asthma. The specific mechanisms and clinical applications are worth further examination. This article reviews the recent research on the role of microRNAs, long non-coding RNAs and circular RNAs in T cells in asthma.

Keywords: Asthma; Circular RNAs; Long non-coding RNAs; Non-coding RNAs; T cells; microRNAs.

Publication types

Review