The application of mesoporous silica nanoparticles as a drug delivery vehicle in oral disease treatment

Lixin Fang; Huoxiang Zhou; Long Cheng; Yiyi Wang; Fei Liu; Suping Wang

doi:10.3389/fcimb.2023.1124411

The application of mesoporous silica nanoparticles as a drug delivery vehicle in oral disease treatment

Front Cell Infect Microbiol. 2023 Feb 14:13:1124411. doi: 10.3389/fcimb.2023.1124411. eCollection 2023.

Authors

Lixin Fang^{1

2}, Huoxiang Zhou^{3

4}, Long Cheng¹, Yiyi Wang¹, Fei Liu¹, Suping Wang¹

Affiliations

¹ Stomatology Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
² The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
³ Laboratory of Microbiology and Immunology, Institute of Medical and Pharmaceutical Sciences & the Beijing Genomics Institution (BGI) College, Zhengzhou University, Zhengzhou, China.
⁴ Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, The Third Affiliated Hospital and Institute of Neuroscience, Zhengzhou University, Zhengzhou, China.

Abstract

Mesoporous silica nanoparticles (MSNs) hold promise as safer and more effective medication delivery vehicles for treating oral disorders. As the drug's delivery system, MSNs adapt to effectively combine with a variety of medications to get over systemic toxicity and low solubility issues. MSNs, which operate as a common nanoplatform for the co-delivery of several compounds, increase therapy effectiveness and show promise in the fight against antibiotic resistance. MSNs offer a noninvasive and biocompatible platform for delivery that produces long-acting release by responding to minute stimuli in the cellular environmen. MSN-based drug delivery systems for the treatment of periodontitis, cancer, dentin hypersensitivity, and dental cavities have recently been developed as a result of recent unparalleled advancements. The applications of MSNs to be embellished by oral therapeutic agents in stomatology are discussed in this paper.

Keywords: biofilm; bone regeneration; dental caries; dentin hypersensitivity; drug delivery system; mesoporous silica nanoparticles (MSNs); oral squamous cell carcinoma.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Oral
Drug Delivery Systems*
Nanoparticles*
Silicon Dioxide
Solubility

Substances

Silicon Dioxide

Grants and funding

The study was supported by National Natural Science Foundation of China grant 81900993 (SW); Henan Provincial Medical Science and Technology Research Plan Provincial Key Project SBGJ202102162 (SW); Henan Provincial Department of Education Key Scientific Research Project of Higher Education Institutions 22A320006 (FL); Henan Province Key R&D and Promotion Special Project (Science and Technology Research) Project 212102310595 (S.W) and 222102310407 (FL).