Rapid selection of a cefiderocol-resistant Escherichia coli producing NDM-5 associated with a single amino acid substitution in the CirA siderophore receptor

Agnès B Jousset; Corentin Poignon; Seher Yilmaz; Alexandre Bleibtreu; Cécile Emeraud; Delphine Girlich; Thierry Naas; Jérôme Robert; Rémy A Bonnin; Laurent Dortet

doi:10.1093/jac/dkad004

Rapid selection of a cefiderocol-resistant Escherichia coli producing NDM-5 associated with a single amino acid substitution in the CirA siderophore receptor

J Antimicrob Chemother. 2023 Apr 3;78(4):1125-1127. doi: 10.1093/jac/dkad004.

Authors

Agnès B Jousset^{1

2

3}, Corentin Poignon¹, Seher Yilmaz⁴, Alexandre Bleibtreu^{5

6}, Cécile Emeraud^{1

2

3}, Delphine Girlich¹, Thierry Naas^{1

2

3}, Jérôme Robert^{4

5}, Rémy A Bonnin^{1

2}, Laurent Dortet^{1

2

3}

Affiliations

¹ Team 'Resist' UMR1184 'Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB)', INSERM, Université Paris-Saclay, CEA, LabEx LERMIT, Faculty of Medicine, Le Kremlin-Bicêtre, France.
² Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
³ Bacteriology-Hygiene Unit, Assistance Publique-Hôpitaux de Paris, AP-HP Paris-Saclay, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
⁴ Bacteriology-Hygiene, AP-HP Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris, France.
⁵ Sorbonne Université, INSERM, U1135, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Équipe 2, Paris, France.
⁶ Service de Maladies Infectieuses et Tropicales, Hôpital Pitié-Salpêtrière, AP-HP. Sorbonne Université, Paris, France.

PMID: 36864015
DOI: 10.1093/jac/dkad004

No abstract available

Publication types

Letter

MeSH terms

Amino Acid Substitution
Anti-Bacterial Agents / pharmacology
Cefiderocol
Cephalosporins / pharmacology
Drug Resistance, Multiple, Bacterial / genetics
Escherichia coli* / genetics
Escherichia coli* / metabolism
Microbial Sensitivity Tests
Siderophores*
beta-Lactamases / metabolism

Substances

Siderophores
Cephalosporins
Anti-Bacterial Agents
beta-Lactamases