Venetoclax plus '2 + 5' modified intensive chemotherapy with daunorubicin and cytarabine in fit elderly patients with untreated de novo acute myeloid leukaemia: a single-centre retrospective analysis

Huafeng Wang; Yiyi Yao; Liping Mao; Yinjun Lou; Yanling Ren; Xingnong Ye; Min Yang; Liya Ma; Yi Zhang; Yile Zhou; Jiaying Wu; Xin Huang; Yungui Wang; Huan Xu; Hongyan Tong; Hong-Hu Zhu; Jie Jin

doi:10.1111/bjh.18709

Venetoclax plus '2 + 5' modified intensive chemotherapy with daunorubicin and cytarabine in fit elderly patients with untreated de novo acute myeloid leukaemia: a single-centre retrospective analysis

Br J Haematol. 2023 May;201(3):568-572. doi: 10.1111/bjh.18709. Epub 2023 Mar 2.

Authors

Huafeng Wang^{1

2

3

4}, Yiyi Yao^{1

2}, Liping Mao^{1

2}, Yinjun Lou^{1

2

4}, Yanling Ren^{1

2}, Xingnong Ye^{1

2}, Min Yang^{1

2}, Liya Ma^{1

2}, Yi Zhang^{1

2}, Yile Zhou^{1

2}, Jiaying Wu⁵, Xin Huang^{1

2

3

4}, Yungui Wang^{1

2

3

4}, Huan Xu^{1

2}, Hongyan Tong^{1

2

3

4}, Hong-Hu Zhu^{1

2

3

4}, Jie Jin^{1

2

3

4}

Affiliations

¹ Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, P.R. China.
² Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy, Zhejiang University, Hangzhou, P.R. China.
³ Zhejiang University Cancer Center, Hangzhou, P.R. China.
⁴ Zhejiang Provincial Clinical Research Center for Hematological Disorders, Hangzhou, P.R. China.
⁵ Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.

PMID: 36863709
DOI: 10.1111/bjh.18709

No abstract available

Keywords: DAV; acute myeloid leukaemia; efficacy; safety; venetoclax.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Bridged Bicyclo Compounds, Heterocyclic / therapeutic use
Cytarabine / therapeutic use
Daunorubicin* / therapeutic use
Humans
Leukemia, Myeloid, Acute* / etiology
Remission Induction
Retrospective Studies

Substances

Daunorubicin
Cytarabine
venetoclax
Bridged Bicyclo Compounds, Heterocyclic