Safety and incidence of COVID-19 following ChAdOx1(AZD1222) COVID-19 vaccination in Botswana

Emily Shava; Alane Izu; Tendani Gaolathe; Adam Walker; Lucy Carty; Panayiotis Georgiou; Lesego Kuate; Coulson Kgathi; Tumalano Sekoto; Ngozana Seonyatseng; Tuelo Mogashoa; Comfort Maphorisa; Terence Mohammed; Tshenolo Ntalabgwe; Tshepho T Frank; Boitumelo Matlhaku; Ame Diphoko; Thandie Phindela; Agripa Kaunda; Poloko Kgari; Thomas Kanyakula; Gape Palalani; Isabella Phakedi; (Botswana AZD1222 study team); Sylvia Taylor; Mompati Mmalane; Sikhulile Moyo; Joseph Makhema

doi:10.1016/j.jinf.2023.02.037

Safety and incidence of COVID-19 following ChAdOx1(AZD1222) COVID-19 vaccination in Botswana

J Infect. 2023 Jun;86(6):603-606. doi: 10.1016/j.jinf.2023.02.037. Epub 2023 Mar 1.

Authors

Emily Shava¹, Alane Izu², Tendani Gaolathe³, Adam Walker⁴, Lucy Carty⁵, Panayiotis Georgiou⁶, Lesego Kuate⁷, Coulson Kgathi⁸, Tumalano Sekoto⁹, Ngozana Seonyatseng¹⁰, Tuelo Mogashoa¹¹, Comfort Maphorisa¹², Terence Mohammed¹³, Tshenolo Ntalabgwe¹⁴, Tshepho T Frank¹⁵, Boitumelo Matlhaku¹⁶, Ame Diphoko¹⁷, Thandie Phindela¹⁸, Agripa Kaunda¹⁹, Poloko Kgari²⁰, Thomas Kanyakula²¹, Gape Palalani²², Isabella Phakedi²³; (Botswana AZD1222 study team)²⁴; Sylvia Taylor²⁵, Mompati Mmalane²⁶, Sikhulile Moyo²⁷, Joseph Makhema²⁸

Affiliations

¹ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: emakunike@gmail.com.
² South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Innovation/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: alane.izu@wits-vida.org.
³ Harvard T.H. Chan School of Public Health, Department of Immunology and Infectious Diseases, Boston, United States; University of Botswana, Gaborone, Botswana. Electronic address: gaolathet@gmail.com.
⁴ Medical Evidence, Vaccine and Immune Therapies, BioPharmaceuticals Medicine, AstraZeneca, Cambridge, UK. Electronic address: adam.walker@astrazeneca.com.
⁵ Medical and Payer Evidence Statistics, BioPharmaceuticals Medicine, AstraZeneca, Cambridge, UK. Electronic address: lucy.carty@astrazeneca.com.
⁶ Late Development, Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. Electronic address: panos.georgiou@astrazeneca.com.
⁷ Ministry of Health Botswana, Botswana. Electronic address: drkuate@gmail.com.
⁸ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: ckgathi@bhp.org.bw.
⁹ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: tsekoto@bhp.org.bw.
¹⁰ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: nseonyatseng@bhp.org.bw.
¹¹ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: tmogashoa@bhp.org.bw.
¹² Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: cmaphorisa@bhp.org.bw.
¹³ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: tmohammed@bhp.org.bw.
¹⁴ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: tntalabgwe@bhp.org.bw.
¹⁵ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: tfrank@bhp.org.bw.
¹⁶ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: bmatlhaku@bhp.org.bw.
¹⁷ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: adiphoko@bhp.org.bw.
¹⁸ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: tphindela@bhp.org.bw.
¹⁹ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: akaunda@bhp.org.bw.
²⁰ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: pkgari@bhp.org.bw.
²¹ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: tkanyakula@bhp.org.bw.
²² Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: gpalalani@bhp.org.bw.
²³ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: phakedi@bhp.org.bw.
²⁴ Botswana Harvard AIDS Institute Partnership, Botswana.
²⁵ Infection Evidence Strategy, Vaccine and Immune Therapies, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK. Electronic address: sylvia.taylor@astrazeneca.com.
²⁶ Botswana Harvard AIDS Institute Partnership, Botswana. Electronic address: mmmalane@bhp.org.bw.
²⁷ Botswana Harvard AIDS Institute Partnership, Botswana; Harvard T.H. Chan School of Public Health, Department of Immunology and Infectious Diseases, Boston, United States. Electronic address: smoyo@bhp.org.bw.
²⁸ Botswana Harvard AIDS Institute Partnership, Botswana; Harvard T.H. Chan School of Public Health, Department of Immunology and Infectious Diseases, Boston, United States. Electronic address: jmakhema@bhp.org.bw.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Viral
Botswana / epidemiology
COVID-19 Vaccines / adverse effects
COVID-19* / prevention & control
ChAdOx1 nCoV-19*
Humans
Incidence
Vaccination / adverse effects

Substances

ChAdOx1 nCoV-19
COVID-19 Vaccines
Antibodies, Viral

Grants and funding

K43 TW012350/TW/FIC NIH HHS/United States