Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study

Martin Munthe Thomsen; Lea Munthe-Fog; Pelle Trier Petersen; Thore Hillig; Lennart Jan Friis-Hansen; Casper Roed; Zitta Barrella Harboe; Christian Thomas Brandt

doi:10.1371/journal.pone.0282004

Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study

PLoS One. 2023 Mar 2;18(3):e0282004. doi: 10.1371/journal.pone.0282004. eCollection 2023.

Authors

Martin Munthe Thomsen¹, Lea Munthe-Fog², Pelle Trier Petersen¹, Thore Hillig³, Lennart Jan Friis-Hansen⁴, Casper Roed¹, Zitta Barrella Harboe^{1

5}, Christian Thomas Brandt^{1

5

6}

Affiliations

¹ Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital, Hillerød, North Zealand, Denmark.
² Stemform/StemMedical, Cell Production and RnD, Søborg, Copenhagen Region, Denmark.
³ Department of Clinical Biochemistry, Copenhagen University Hospital, Hillerød, North Zealand, Denmark.
⁴ Department of Clinical Biochemistry, University Hospitals Bispebjerg and Frederiksberg, University of Copenhagen, Copenhagen, Denmark.
⁵ Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Region, Copenhagen, Denmark.
⁶ Department of Infectious Diseases, Zealand University Hospital, University of Copenhagen, Roskilde, Denmark.

Abstract

The present study describes diagnostic and prognostic abilities of Cerebrospinal fluid (CSF) Pentraxin 3 (PTX3) in central nervous system (CNS) infections. CSF PTX3 was measured retrospectively from 174 patients admitted under suspicion of CNS infection. Medians, ROC curves and Youdens index was calculated. CSF PTX3 was significantly higher among all CNS infections and undetectable in most of the patients in the control group, and significantly higher in bacterial infections compared to viral and Lyme infections. No association was found between CSF PTX3 and Glasgow Outcome Score. PTX3 in the CSF can distinguish bacterial infection from viral and Lyme infections and non-CNS infections. Highest levels were found in bacterial meningitis. No prognostic abilities were found.

Copyright: © 2023 Thomsen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

C-Reactive Protein
Central Nervous System Infections*
Humans
Lyme Disease*
Retrospective Studies

Substances

PTX3 protein
C-Reactive Protein

Grants and funding

Receiver of grant: MMT Funder: Nordsjællands Hospital Url: https://www.nordsjaellandshospital.dk/forskning/Sider/default.aspx The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.