[Research Progressin the Relationship between Interleukin-6 and Intervertebral Disc Degeneration]

Jin-Lei Chen; Shuang Wang; Ming-Chuan Wang; Xin Wang

doi:10.3881/j.issn.1000-503X.14709

[Research Progressin the Relationship between Interleukin-6 and Intervertebral Disc Degeneration]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2023 Feb;45(1):134-142. doi: 10.3881/j.issn.1000-503X.14709.

[Article in Chinese]

Authors

Jin-Lei Chen¹, Shuang Wang², Ming-Chuan Wang¹, Xin Wang^{1

3

4}

Affiliations

¹ The First Clinical Medical School of Lanzhou University,Lanzhou 730000,China.
² School of Public Health,Lanzhou University,Lanzhou 730000,China.
³ Department of Orthopedics,905th Hospital,Naval Medical University,Shanghai 200003,China.
⁴ Department of Spine,Changzheng Hospital,Naval Medical University,Shanghai 200003,China.

PMID: 36861167
DOI: 10.3881/j.issn.1000-503X.14709

Abstract

Intervertebral disc degeneration (IDD) is one of the main diseases causing low back pain,which seriously affects the quality of life of patients.Recent studies have discovered that interleukin-6 (IL-6) is highly expressed in the tissues and cells of degenerative intervertebral disc and is closely related to the occurrence and development of IDD.However,the signaling pathway and role of IL-6 in IDD remain to be understood.Therefore,this article reviews the recent studies about the signaling pathway and role of IL-6 in IDD,aiming to facilitate the clinical work and subsequent research progress.

Keywords: inflammatory responses; interleukin-6; intervertebral disc degeneration.

Publication types

Review
English Abstract

MeSH terms

Humans
Interleukin-6*
Intervertebral Disc Degeneration*
Peptides
Quality of Life

Substances

Interleukin-6
progressin
Peptides