Function, structure, evolution, regulation of a potent drug target, arylalkylamine N-acetyltransferase

Lei Zhang; Yu Tang; David J Merkler; Qian Han

doi:10.1016/bs.apcsb.2022.11.002

Function, structure, evolution, regulation of a potent drug target, arylalkylamine N-acetyltransferase

Adv Protein Chem Struct Biol. 2023:134:211-223. doi: 10.1016/bs.apcsb.2022.11.002. Epub 2022 Dec 1.

Authors

Lei Zhang¹, Yu Tang¹, David J Merkler², Qian Han³

Affiliations

¹ Laboratory of Tropical Veterinary Medicine and Vector Biology, School of Life Sciences, Hainan University, Haikou, Hainan, P.R. China; One Health Institute, Hainan University, Haikou, Hainan, P.R. China.
² Department of Chemistry, University of South Florida, Tampa, FL, United States.
³ Laboratory of Tropical Veterinary Medicine and Vector Biology, School of Life Sciences, Hainan University, Haikou, Hainan, P.R. China; One Health Institute, Hainan University, Haikou, Hainan, P.R. China. Electronic address: qianhan@hainanu.edu.cn.

PMID: 36858736
DOI: 10.1016/bs.apcsb.2022.11.002

Abstract

Arylalkylamine N-acetyltransferase (aaNAT) catalyzes the transacetylation of acetyl coenzyme A to arylamines and arylalkylamines. Based on three-dimensional structural information, aaNAT belongs to the GCN5-related N-acetyltransferases superfamily with a conserved acetyl-CoA binding domain (Dyda et al., 2000). By comparison of sequence similarity, aaNAT is usually divided into vertebrate aaNAT (VT-aaNAT) and non-vertebrate aaNAT (NV-aaNAT) (Cazaméa-Catalan et al., 2014). Insects have evolved multiple aaNATs in comparison to mammals, thus more diverse functions are also reflected in insects. This chapter will summarize previous studies on the function, regulation, structure and evolution of aaNAT, and provide insight into future pest management.

Keywords: Acetyl-CoA; Arylalkylamine N-acetyltransferase; Evolution; Function; Regulation; Structure; aaNAT.

MeSH terms

Amines*
Animals
Arylalkylamine N-Acetyltransferase*
Drug Delivery Systems

Substances

Amines
Arylalkylamine N-Acetyltransferase