Muyocoxanthones O-S: Undescribed xanthones with antioxidative damage bioactivity to cardiomyocytes from the endophytic fungus Muyocopron laterale

Hai-Yan Cao; Sen-Feng Sun; Cheng Yi; Chen-Yu Yang; Ke-Liang Chen; Xiao-Wei Zhang; Yun-Bao Liu

doi:10.1016/j.phytochem.2023.113625

Muyocoxanthones O-S: Undescribed xanthones with antioxidative damage bioactivity to cardiomyocytes from the endophytic fungus Muyocopron laterale

Phytochemistry. 2023 May:209:113625. doi: 10.1016/j.phytochem.2023.113625. Epub 2023 Feb 27.

Authors

Hai-Yan Cao¹, Sen-Feng Sun², Cheng Yi², Chen-Yu Yang², Ke-Liang Chen², Xiao-Wei Zhang², Yun-Bao Liu³

Affiliations

¹ State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100050, China.
² State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
³ State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: liuyunbao@imm.ac.cn.

PMID: 36858338
DOI: 10.1016/j.phytochem.2023.113625

Abstract

The metabolites from the endophytic fungus Muyocopron laterale hosted in the medicinal plant Tylophora ovata were investigated, and five undescribed xanthones, muyocoxanthones O-S, along with seven known compounds were isolated. Their structures were elucidated by HR-ESI-MS, NMR, and ECD calculations. Compounds were evaluated for their anti-cardiomyocyte oxidative damage activity using a model of oxidative damage induced by cell hypoxia incubation. Muyocoxanthones O-Q and blennolide L exhibited moderate activity against oxidative damage to cardiomyocytes with relative viabilities of 62.4, 54.8, 60.3 and 54.9%, respectively.

Keywords: Antioxidative damage; Endophytic fungus; Muyocopron laterale; Tylophora ovata; Xanthones.

MeSH terms

Antioxidants / pharmacology
Ascomycota* / chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Xanthones* / chemistry

Substances

Antioxidants
Xanthones

Supplementary concepts

Muyocopron laterale