Cardiorespiratory coupling as an early marker of cardiac autonomic dysfunction in type 2 diabetes mellitus patients

Claudio Donisete Da Silva; Aparecida Maria Catai; Raphael Martins de Abreu; Étore De Favari Signini; Gabriela Aguiar Mesquita Galdino; Laura Lorevice; Letícia Menegalli Santos; Renata Gonçalves Mendes

doi:10.1016/j.resp.2023.104042

Cardiorespiratory coupling as an early marker of cardiac autonomic dysfunction in type 2 diabetes mellitus patients

Respir Physiol Neurobiol. 2023 May:311:104042. doi: 10.1016/j.resp.2023.104042. Epub 2023 Feb 27.

Authors

Claudio Donisete Da Silva¹, Aparecida Maria Catai², Raphael Martins de Abreu³, Étore De Favari Signini², Gabriela Aguiar Mesquita Galdino², Laura Lorevice¹, Letícia Menegalli Santos¹, Renata Gonçalves Mendes⁴

Affiliations

¹ Cardiopulmonary Physical Therapy Laboratory, Department of Physical Therapy, Federal University of São Carlos, Brazil.
² Cardiovascular Physical Therapy Laboratory, Department of Physical Therapy, Federal University of São Carlos, Brazil.
³ LUNEX University, International University of Health, Exercise & Sports S.A. 50, Department of Physiotherapy, Differdange, Luxembourg. 50 Avenue du Parc des Sports, L-4671, Differdange, Luxembourg; LUNEX ASBL Luxembourg Health & Sport Sciences Research Institute, Differdange, Luxembourg. 50 Avenue du Parc des Sports, L-4671, Differdange, Luxembourg.
⁴ Cardiopulmonary Physical Therapy Laboratory, Department of Physical Therapy, Federal University of São Carlos, Brazil. Electronic address: renatamendes@ufscar.br.

PMID: 36858335
DOI: 10.1016/j.resp.2023.104042

Abstract

The aim of this study was to assess cardiorespiratory coupling (CRC) in type 2 diabetes mellitus patients (T2DM) and apparently healthy individuals, in order to test the hypothesis that this method can provide additional knowledge to the information obtained through the heart rate variability (HRV). A cross-sectional study was conducted in T2DM patients(T2DMG=32) and health controls (CON=32). For CRC analysis, the electrocardiogram, arterial pressure, and thoracic respiratory movement were recorded at rest in supine position and during active standing. Beat-to-beat series of heart period and systolic arterial pressure were analyzed with the respiratory movement signal via a traditional non-causal approach, such as squared coherence function. In this sample of T2DM, no differences in HRV were observed when compared to the CON, but the T2DMG showed a reduction in resting CRC. We conclude that in CRC in T2DM, reflected by the squared coherence may already be compromised even before HRV changes.

Keywords: Autonomic nervous system; Cardiac control; Heart rate variability; Type 2 diabetes mellitus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autonomic Nervous System
Autonomic Nervous System Diseases* / diagnosis
Autonomic Nervous System Diseases* / etiology
Cross-Sectional Studies
Diabetes Mellitus, Type 2* / complications
Heart
Heart Diseases*
Heart Rate / physiology
Humans