Synergetic effects of Mo2C sphere/SCN nanocatalysts interface for nanomolar detection of uric acid and folic acid in presence of interferences

Pattan-Siddappa Ganesh; Mani Govindasamy; Sang-Youn Kim; Dong-Soo Choi; Hyun-U Ko; Razan Abdullah Alshgari; Chi-Hsien Huang

doi:10.1016/j.ecoenv.2023.114694

Synergetic effects of Mo₂C sphere/SCN nanocatalysts interface for nanomolar detection of uric acid and folic acid in presence of interferences

Ecotoxicol Environ Saf. 2023 Mar 15:253:114694. doi: 10.1016/j.ecoenv.2023.114694. Epub 2023 Feb 27.

Authors

Pattan-Siddappa Ganesh¹, Mani Govindasamy², Sang-Youn Kim³, Dong-Soo Choi⁴, Hyun-U Ko¹, Razan Abdullah Alshgari⁵, Chi-Hsien Huang⁶

Affiliations

¹ Interaction Laboratory, Future Convergence Engineering, Advanced Technology Research Center, Korea University of Technology and Education, Cheonan-si 31253, Chungcheongnam-do, Republic of Korea.
² Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan; Full-time faculty, International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City, 243303, Taiwan; Department of Research and Innovation, Saveetha School of Engineering, SIMATS, Chennai 602105, India.
³ Interaction Laboratory, Future Convergence Engineering, Advanced Technology Research Center, Korea University of Technology and Education, Cheonan-si 31253, Chungcheongnam-do, Republic of Korea. Electronic address: sykim@koreatech.ac.kr.
⁴ Smart Interface and Extended Reality Laboratory, Department of Computer Engineering, Kumoh National Institute of Technology, Gumi 39177, Republic of Korea.
⁵ Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
⁶ Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan. Electronic address: chhuang@mail.mcut.edu.tw.

PMID: 36857924
DOI: 10.1016/j.ecoenv.2023.114694

Abstract

Till to date, the application of sulfur-doped graphitic carbon nitride supported transition metal carbide interface for electrochemical sensor fabrication was less explored. In this work, we designed a simple synthesis of molybdenum carbide sphere embedded sulfur doped graphitic carbon nitride (Mo₂C/SCN) catalyst for the nanomolar electrochemical sensor application. The synthesized Mo₂C/SCN nanocatalyst was systematically characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM) with elemental mapping. The SEM images show that the porous SCN network adhered uniformly on Mo₂C, causing a loss of crystallinity in the diffractogram. The corresponding elemental mapping of Mo₂C/SCN shows distinct peaks for carbon (41.47%), nitrogen (32.54%), sulfur (1.37%), and molybdenum (24.62%) with no additional impurity peaks, reflecting the successful synthesis. Later, the glassy carbon electrode (GCE) was modified by Mo₂C/SCN nanocatalyst for simultaneous sensing of uric acid (UA) and folic acid (FA). The fabricated Mo₂C/SCN/GCE is capable of simultaneous and interference free electrochemical detection of UA and FA in a binary mixture. The limit of detection (LOD) calculated at Mo₂C/SCN/GCE for UA and FA was 21.5 nM (0.09 - 47.0 μM) and 14.7 nM (0.09 - 167.25 μM) respectively by differential pulse voltammetric (DPV) technique. The presence of interferons has no significant effect on the sensor's performance, making it suitable for real sample analysis. The present method can be extended to fabricate an electrochemical sensor for various molecules.

Keywords: Electrocatalyst; Electrochemical sensing; Nanosensor; Real samples; Transition metal carbides.

MeSH terms

Carbon / chemistry
Electrochemical Techniques / methods
Electrodes
Folic Acid*
Limit of Detection
Sulfur
Uric Acid* / analysis

Substances

Folic Acid
graphitic carbon nitride
Uric Acid
Carbon
Sulfur