Obesogenic effect of Bisphenol P on mice via altering the metabolic pathways

Wenjuan Zhang; Xuerui Ma; Yijia Zhang; Wanjing Tong; Xing Zhang; Yong Liang; Maoyong Song

doi:10.1016/j.ecoenv.2023.114703

Obesogenic effect of Bisphenol P on mice via altering the metabolic pathways

Ecotoxicol Environ Saf. 2023 Mar 15:253:114703. doi: 10.1016/j.ecoenv.2023.114703. Epub 2023 Feb 28.

Authors

Wenjuan Zhang¹, Xuerui Ma², Yijia Zhang², Wanjing Tong², Xing Zhang³, Yong Liang², Maoyong Song⁴

Affiliations

¹ Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, 430056 Wuhan, China; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
² Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, 430056 Wuhan, China.
³ Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity, College of Urban and Environmental Science, Northwest University, Xi'an 710127, China.
⁴ Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, 430056 Wuhan, China; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: mysong@rcees.ac.cn.

PMID: 36857923
DOI: 10.1016/j.ecoenv.2023.114703

Abstract

Bisphenol P (BPP), structurally similar to bisphenol A, is commonly identified in the samples of environment, food, and humans. Unfortunately, very little information is currently available on adverse effects of BPP. The obesogenic effects and underlying mechanisms of BPP on mice were investigated in this study. Compared with the control, high-resolution microcomputed tomography (micro-CT) scans displayed that the visceral fat volume of mice was significantly increased at a dose of 5 mg/kg/day after BPP exposure for 14 days, whereas the subcutaneous fat volume remained unchanged. Nontargeted metabolomic analysis revealed that BPP significantly perturbed the metabolic pathways of mouse livers, and acetyl-CoA was identified as the potential key metabolite responsible for the visceral fat induced by BPP. These findings recommend that a great deal of attention should be paid to the obesogenic properties of BPP as a result of its widely utilized and persistence in the environment.

Keywords: Acetyl-CoA; Bisphenol P; Metabolic disorders; Obesogenic effects; Visceral obesity.

MeSH terms

Animals
Benzhydryl Compounds* / toxicity
Humans
Metabolic Networks and Pathways
Mice
Phenols* / toxicity
X-Ray Microtomography

Substances

bisphenol A
Phenols
Benzhydryl Compounds