Herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma

Maria K Jauhiainen; Ushanandini Mohanraj; Martin Lehecka; Mika Niemelä; Timo P Hirvonen; Diogo Pratas; Maria F Perdomo; Maria Söderlund-Venermo; Antti A Mäkitie; Saku T Sinkkonen

doi:10.1007/s13365-023-01112-8

Herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma

J Neurovirol. 2023 Apr;29(2):226-231. doi: 10.1007/s13365-023-01112-8. Epub 2023 Mar 1.

Authors

Maria K Jauhiainen^{1

2

3

4}, Ushanandini Mohanraj⁵, Martin Lehecka⁶, Mika Niemelä⁶, Timo P Hirvonen⁷, Diogo Pratas^{5

8}, Maria F Perdomo⁵, Maria Söderlund-Venermo⁵, Antti A Mäkitie^{7

9}, Saku T Sinkkonen⁷

Affiliations

¹ Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, POB 263, 00029, Helsinki, Finland. maria.jauhiainen@hus.fi.
² Department of Virology, University of Helsinki, Helsinki, Finland. maria.jauhiainen@hus.fi.
³ Faculty of Medicine, Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland. maria.jauhiainen@hus.fi.
⁴ Faculty of Medicine, The Doctoral Programme in Clinical Research, University of Helsinki, Helsinki, Finland. maria.jauhiainen@hus.fi.
⁵ Department of Virology, University of Helsinki, Helsinki, Finland.
⁶ Department of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
⁷ Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, POB 263, 00029, Helsinki, Finland.
⁸ Department of Electronics, Telecommunications and Informatics and Institute of Electronics and Informatics Engineering of Aveiro, University of Aveiro, Aveiro, Portugal.
⁹ Faculty of Medicine, Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland.

Abstract

Etiology of vestibular schwannoma (VS) is unknown. Viruses can infect and reside in neural tissues for decades, and new viruses with unknown tumorigenic potential have been discovered. The presence of herpesvirus, polyomavirus, parvovirus, and anellovirus DNA was analyzed by quantitative PCR in 46 formalin-fixed paraffin-embedded VS samples. Five samples were analyzed by targeted next-generation sequencing. Viral DNA was detected altogether in 24/46 (52%) tumor samples, mostly representing anelloviruses (46%). Our findings show frequent persistence of anelloviruses, considered normal virome, in VS. None of the other viruses showed an extensive presence, thereby suggesting insignificant role in VS.

Keywords: Anellovirus; Herpesvirus; Parvovirus; Polyomavirus; Vestibular schwannoma; Viral etiology.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anelloviridae* / genetics
DNA, Viral / genetics
Herpesviridae* / genetics
Humans
Neuroma, Acoustic* / genetics
Parvovirus* / genetics
Polyomavirus* / genetics

Substances

DNA, Viral