Lessons for the clinical nephrologist: a rare case with MGRS characterized by combined crystalline light chain proximal tubulopathy and crystal-storing histiocytosis responding to daratumumab

Ai-Bo Qin; Xiao-Juan Yu; Xi-Zi Zheng; Su-Xia Wang; Fu-de Zhou; Ming-Hui Zhao

doi:10.1007/s40620-023-01584-1

Lessons for the clinical nephrologist: a rare case with MGRS characterized by combined crystalline light chain proximal tubulopathy and crystal-storing histiocytosis responding to daratumumab

J Nephrol. 2023 May;36(4):1203-1207. doi: 10.1007/s40620-023-01584-1. Epub 2023 Mar 1.

Authors

Ai-Bo Qin^{1

2

3

4

5

6}, Xiao-Juan Yu^{1

2

3

4

5

6}, Xi-Zi Zheng^{1

2

3

4

5

6}, Su-Xia Wang^{1

2

3

4

5

6

7}, Fu-de Zhou^{8

9

10

11

12

13}, Ming-Hui Zhao^{1

2

3

4

5

6

14}

Affiliations

¹ Renal Division, Department of Medicine, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing, China.
² Institute of Nephrology, Peking University, Beijing, China.
³ Renal Pathology Center, Institute of Nephrology, Peking University, Beijing, China.
⁴ Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China.
⁵ Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.
⁶ Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China.
⁷ Laboratory of Electron Microscopy, Pathological Centre, Peking University First Hospital, Beijing, Beijing, 100034, China.
⁸ Renal Division, Department of Medicine, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing, China. zhoufude1801@vip.sina.com.
⁹ Institute of Nephrology, Peking University, Beijing, China. zhoufude1801@vip.sina.com.
¹⁰ Renal Pathology Center, Institute of Nephrology, Peking University, Beijing, China. zhoufude1801@vip.sina.com.
¹¹ Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China. zhoufude1801@vip.sina.com.
¹² Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. zhoufude1801@vip.sina.com.
¹³ Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China. zhoufude1801@vip.sina.com.
¹⁴ Peking-Tsinghua Center for Life Sciences, Beijing, China.

No abstract available

Keywords: Crystal-storing histiocytosis; Daratumumab; Light chain proximal tubulopathy; Monoclonal gammopathy; Monoclonal gammopathy of renal significance.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Histiocytosis* / diagnosis
Histiocytosis* / drug therapy
Humans
Kidney Diseases*
Nephrologists
Paraproteinemias*

Substances

daratumumab

Publication types

MeSH terms

Substances

Grants and funding