Early-Onset Colorectal Cancer Somatic Gene Mutations by Population Subgroups

Xinyi Shen; Andrew T DeWan; Caroline H Johnson

doi:10.1158/2159-8290.CD-22-1464

Early-Onset Colorectal Cancer Somatic Gene Mutations by Population Subgroups

Cancer Discov. 2023 Mar 1;13(3):530-531. doi: 10.1158/2159-8290.CD-22-1464.

Authors

Xinyi Shen¹, Andrew T DeWan², Caroline H Johnson¹

Affiliations

¹ Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, Connecticut.
² Department of Chronic Disease Epidemiology and Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health, Yale University, New Haven, Connecticut.

PMID: 36855917
DOI: 10.1158/2159-8290.CD-22-1464

Abstract

In this issue of Cancer Discovery, Holowatyj and colleagues uncover racial/ethnic and sex heterogeneity in somatic mutations among patients with early-onset colorectal cancer. The findings shed light on a deeper understanding of complex biological and genetic mechanisms for colorectal cancer in diverse populations. See related article by Holowatyj et al., p. 570 (6).

Publication types

Editorial
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Colorectal Neoplasms* / genetics
Female
Genes, Neoplasm
Humans
Male
Mutation
Sex Characteristics*