Melanoma is the most aggressive skin cancer, and surgery is the standard of care for localised disease. However, a risk of local and distant relapse exists despite tumour removal, particularly with thick or ulcerated tumours or lymph node involvement. Immunotherapy with immune checkpoint inhibitors (ICIs) targeting PD-1, PD-L-1 or CTLA-4 demonstrated improved relapse-free survival and distant metastasis-free survival against placebo after surgery for stage-III and high-risk stage-II melanoma. In unresectable localised and metastatic tumours, the double immunotherapy with ICIs (anti-PD-1+ anti-CTLA-4) allows for long-term survival in more than 50% of the patients. Novel immunotherapies (anti-LAG-3 ICI, adoptive cell therapy, intra-tumoural immunotherapy, cancer vaccines) and new combinations are in development to overcome resistance and improve patients' survival. Therapeutic decisions for each patient should be discussed in a specialised multidisciplinary team.
Keywords: Immun-Checkpoint-Inhibitoren; Krebsimmuntherapie; Melanom; Melanoma; Mélanome; adoptive Zelltherapie; adoptive cell therapy; cancer immunotherapy; immune checkpoint inhibitors; immunothérapie des cancers; inhibiteurs de points de contrôle immunitaire; oncolytic viruses; onkolytische Viren; thérapie cellulaire adoptive; virus oncolytiques.