The Future of Diabetes Therapies: New Insulins and Insulin Delivery Systems, Glucagon-Like Peptide 1 Analogs, Sodium-Glucose Cotransporter Type 2 Inhibitors, and Beta Cell Replacement Therapy

Vet Clin North Am Small Anim Pract. 2023 May;53(3):675-690. doi: 10.1016/j.cvsm.2023.01.003. Epub 2023 Feb 26.

Abstract

As the prevalence of diabetes mellitus increases, so too does the number of available treatment modalities. Many diabetic therapies available in human medicine or on the horizon could hold promise in the management of small animal diabetes. However, it is important to consider how species differences in pathophysiology, management practices and goals, and lifestyle may affect the translation of such treatment modalities for veterinary use. This review article aimed to familiarize veterinarians with the more promising novel diabetic therapies and explore their possible applications in the treatment of canine and feline diabetes mellitus.

Keywords: Beta cell replacement therapy; GLP-1 analogs; Insulin infusion pump; SGLT-2 inhibitors; Smart insulin; Ultra-long-acting insulin analogs.

Publication types

  • Review

MeSH terms

  • Animals
  • Cat Diseases* / drug therapy
  • Cats
  • Diabetes Mellitus, Type 2* / metabolism
  • Diabetes Mellitus, Type 2* / veterinary
  • Dog Diseases* / drug therapy
  • Dogs
  • Glucagon-Like Peptide 1
  • Glucose
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Insulin / therapeutic use
  • Sodium

Substances

  • Insulin
  • Glucagon-Like Peptide 1
  • Hypoglycemic Agents
  • Glucose
  • Sodium