The global burden of colorectal cancer attributable to high plasma glucose in 204 countries and territories, 1990-2019: an analysis of the Global Burden of Disease Study

Bin Yang; Youyou Lv; Oumin Shi; Mengqing Yan; Xiao Li; Wenjun Kang; Yongli Yang; Wei Wang; Qi Wang

doi:10.1016/j.puhe.2023.01.024

The global burden of colorectal cancer attributable to high plasma glucose in 204 countries and territories, 1990-2019: an analysis of the Global Burden of Disease Study

Public Health. 2023 Apr:217:46-53. doi: 10.1016/j.puhe.2023.01.024. Epub 2023 Feb 26.

Authors

Bin Yang¹, Youyou Lv², Oumin Shi³, Mengqing Yan¹, Xiao Li¹, Wenjun Kang¹, Yongli Yang⁴, Wei Wang⁵, Qi Wang⁶

Affiliations

¹ Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China; The Key Laboratory of Nanomedicine and Health Inspection of Zhengzhou, Zhengzhou, 450001, China.
² Department of Anesthesiology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, 519000, China.
³ Health Science Center, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, 518020, China.
⁴ Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China.
⁵ Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China; The Key Laboratory of Nanomedicine and Health Inspection of Zhengzhou, Zhengzhou, 450001, China. Electronic address: ww375@zzu.edu.cn.
⁶ Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China; China-Canada Medical and Healthcare Science Association, Toronto, ON, L3R 1A3, Canada. Electronic address: qi.wang@ccmhsa.org.

PMID: 36854250
DOI: 10.1016/j.puhe.2023.01.024

Abstract

Objectives: This study aimed to estimate the burden of colorectal cancer (CRC) attributable to high plasma glucose from 1990 to 2019.

Study design and methods: Data on the disease burden were retrieved from the Global Burden of Disease online database. Estimated average percentage change (EAPC) was used to quantify the age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life years (DALYs) rate (ASDR) of high plasma glucose-related CRC trends by sex and location between 1990 and 2019.

Results: Globally, the death number and DALYs of CRC attributable to high plasma glucose remained a steady increase at global level from 1990 to 2019, and similar trends have been reported in age-standardized rate. The country with the largest number of death cases and DALYs of high plasma glucose-related CRC in 2019 was China, followed by the United States of America and India. Nearly three-quarters of total countries experienced an increase in the ASMR and ASDR, and the greatest increase of ASMR and ASDR was found in Uzbekistan (EAPC = 5.32) and Equatorial Guinea (EAPC = 4.65), respectively. A negative correlation was found between sociodemographic indices and the EAPC of ASMR and ASDR (r_ASMR = -0.259, p < 0.001; r_ASDR = -0.282, p < 0.001).

Conclusions: A significant increase in mortality and DALYs of CRC attributable to high plasma glucose was observed in global and most countries, especially in the developing countries. Public health policies and targeted programs are needed to reduce the burden of disease.

Keywords: Colorectal cancer; Disability-adjusted life years; Global Burden of Disease; High plasma glucose; Mortality.

MeSH terms

Blood Glucose*
Colorectal Neoplasms*
Cost of Illness
Global Burden of Disease
Global Health
Humans
Quality-Adjusted Life Years

Substances

Blood Glucose