Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells

Maryam Farzaneh; Ava Nasrolahi; Farhoodeh Ghaedrahmati; Tariq Masoodi; Sajad Najafi; Mohadeseh Sheykhi-Sabzehpoush; Mahrokh Abouali Gale Dari; Klaudia Radoszkiewicz; Shahab Uddin; Shirin Azizidoost; Seyed Esmaeil Khoshnam

doi:10.1007/s12094-023-03110-y

Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells

Clin Transl Oncol. 2023 Jul;25(7):2015-2042. doi: 10.1007/s12094-023-03110-y. Epub 2023 Feb 28.

Affiliations

¹ Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
² Infectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
³ Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
⁴ Laboratory of Molecular and Metabolic Imaging, Cancer Research Department, Sidra Medicine, 26999, Doha, Qatar.
⁵ Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁶ Department of Laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
⁷ Department of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁸ Translational Platform for Regenerative Medicine, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.
⁹ Translational Research Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
¹⁰ Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. shirin_azizidoost@yahoo.com.
¹¹ Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Esmaeil.khoshnam1392@gmail.com.

PMID: 36853400
DOI: 10.1007/s12094-023-03110-y

Abstract

Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers.

Keywords: Cancer; LncRNAs; Pathogenesis; Tumorigenesis; XIST.

Publication types

Review

MeSH terms

Carcinogenesis
Female
Humans
MicroRNAs* / genetics
Neoplasms* / genetics
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism
RNA, Messenger

Substances

MicroRNAs
RNA, Long Noncoding
RNA, Messenger