The Platelet Aggregation Inhibition Activity of Polyphenols can be mediated by 67kda Laminin Receptor: A New Therapeutic Strategy For the Treatment of Venous Thromboembolism

Satya Prakash; Amit Ghosh; Arnab Nayek; Sheetal Kiran

doi:10.2174/1871525721666230228120500

The Platelet Aggregation Inhibition Activity of Polyphenols can be mediated by 67kda Laminin Receptor: A New Therapeutic Strategy For the Treatment of Venous Thromboembolism

Cardiovasc Hematol Agents Med Chem. 2023 Feb 28. doi: 10.2174/1871525721666230228120500. Online ahead of print.

Authors

Satya Prakash¹, Amit Ghosh², Arnab Nayek³, Sheetal Kiran²

Affiliations

¹ Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
² Department of Physiology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
³ Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.

PMID: 36852811
DOI: 10.2174/1871525721666230228120500

Abstract

Background: Thrombotic disease is still a major killer. Aspirin, Ticagrelor, Clopidogrel, etc. are the most widely used conventional antiplatelet drugs. The significant number of patients who are resistant to this drug shows a poor outcome.

Objective: Developing a new antiplatelet agent with a stable antiplatelet effect and minimal bleeding risk is required for a patient who is resistant to antiplatelet drugs.

Method: Protein-ligand docking was performed using Autodock Vina 1.1.2 to study the interaction of 67LR with different Polyphenols.

Result: Among the 18 polyphenols, thearubigin has the highest binding affinity towards 67LR and gallic acid shows the lowest binding affinity. Among the 18 molecules, the top 10 molecules from the highest to lowest binding affinity range from-10.6 (thearubigin) to -6.5 (Epigallocatechin).

Conclusion: Polyphenols may inhibit platelet aggregation through 67 LR and can be an alternative treatment for Thrombotic Disease. Moreover, it will be interesting to know whether polyphenols interfere with the same pathways as aspirin and clopidogrel. Effective polyphenols could help prototype the compound development of novel antiplatelet agents.

Keywords: EGCG; antiplatelet; epigallocatechin; epigallocatechin gallate; flavonoids; laminin receptor; polyphenols.