Sedation Is Associated with Higher Polyp and Adenoma Detection Rates during Colonoscopy: A Retrospective Cohort Study

Chenghu Xu; Dehua Tang; Ying Xie; Muhan Ni; Min Chen; Yonghua Shen; Xiaotan Dou; Lin Zhou; Guifang Xu; Lei Wang; Ying Lv; Shu Zhang; Xiaoping Zou

doi:10.1155/2023/1172478

Sedation Is Associated with Higher Polyp and Adenoma Detection Rates during Colonoscopy: A Retrospective Cohort Study

Gastroenterol Res Pract. 2023 Feb 18:2023:1172478. doi: 10.1155/2023/1172478. eCollection 2023.

Authors

Chenghu Xu¹, Dehua Tang¹, Ying Xie¹, Muhan Ni¹, Min Chen¹, Yonghua Shen¹, Xiaotan Dou¹, Lin Zhou¹, Guifang Xu¹, Lei Wang¹, Ying Lv^{1

2}, Shu Zhang^{1

2}, Xiaoping Zou^{1

2

3}

Affiliations

¹ Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
² Jiangsu Medical Quality Control Center (Digestive Diseases), Nanjing, Jiangsu 210008, China.
³ Department of Gastroenterology, Taikang Xianlin Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210046, China.

Abstract

Background and aims: Currently sedation is a common practice in colonoscopy to reduce pain of patients and improve the operator satisfaction, whereas its impact on examination quality, especially adenoma detection rate (ADR) is still controversial. Thus, we aimed to investigate the association of sedation with ADR.

Methods: Consecutive patients receiving colonoscopy between January 2017 and January 2020 at the Nanjing Drum Tower Hospital, Nanjing, China, were collected. Univariate and multivariate logistic regression models were performed to investigate the association between sedation and ADR. Subgroup analysis and propensity score matching (PSM) analysis, as sensitivity analysis, were performed to validate the independent effect.

Results: The ADR was significantly higher in cases with sedation (ADR: 36.9% vs. 29.1%, odds ratio [OR]: 1.42, 95% confidence interval [CI]: 1.31-1.55, P < 0.001). Multivariate analysis showed that the sedation was an independent factor associated with ADR (OR: 1.49, 95% CI: 1.35-1.65, P < 0.001). The effect was consistent in subgroup analyses (P > 0.05) and PSM analysis (ADR: 37.6% vs. 29.1%, OR: 1.47, 95% CI: 1.33-1.63, P < 0.001).

Conclusion: Sedation was associated with a higher polyp and ADR s during colonoscopy, which can promote the quality of colonoscopy.