Mathematical modeling of regulatory networks of intracellular processes - Aims and selected methods

Malgorzata Kardynska; Daria Kogut; Marcin Pacholczyk; Jaroslaw Smieja

doi:10.1016/j.csbj.2023.02.006

Mathematical modeling of regulatory networks of intracellular processes - Aims and selected methods

Comput Struct Biotechnol J. 2023 Feb 8:21:1523-1532. doi: 10.1016/j.csbj.2023.02.006. eCollection 2023.

Authors

Malgorzata Kardynska¹, Daria Kogut^{1

2}, Marcin Pacholczyk^{1

2}, Jaroslaw Smieja^{1

2}

Affiliations

¹ Dept. of Biosensors and Processing of Biomedical Signals, Silesian University of Technology, Gliwice, Poland.
² Dept. of Systems Biology and Engineering, Silesian University of Technology, Gliwice, Poland.

Abstract

Regulatory networks structure and signaling pathways dynamics are uncovered in time- and resource consuming experimental work. However, it is increasingly supported by modeling, analytical and computational techniques as well as discrete mathematics and artificial intelligence applied to to extract knowledge from existing databases. This review is focused on mathematical modeling used to analyze dynamics and robustness of these networks. This paper presents a review of selected modeling methods that facilitate advances in molecular biology.

Keywords: Modeling; Regulatory networks; Signaling pathways.

Publication types

Review