Baculovirus Display of Peptides and Proteins for Medical Applications

Viruses. 2023 Feb 1;15(2):411. doi: 10.3390/v15020411.

Abstract

Baculoviridae is a large family of arthropod-infective viruses. Recombinant baculoviruses have many applications, the best known is as a system for large scale protein production in combination with insect cell cultures. More recently recombinant baculoviruses have been utilized for the display of proteins of interest with applications in medicine. In the present review we analyze the different strategies for the display of proteins and peptides on the surface of recombinant baculoviruses and provide some examples of the different proteins displayed. We analyze briefly the commercially available systems for recombinant baculovirus production and display and discuss the future of this emerging and powerful technology.

Keywords: GP64; VP39; baculovirus display; vaccines.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arthropods*
  • Baculoviridae* / genetics
  • Cell Culture Techniques
  • Peptides / genetics

Substances

  • Peptides

Grants and funding

This research was funded by a grant (AV200320) from Dirección General de Asuntos del Personal Académico (DGAPA) to LV. T P-F is grateful for the postdoctoral fellowship from Direction General de Asuntos del Personal Académico (DGAPA)-UNAM.