Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma

Cancer Res. 2023 May 2;83(9):1517-1530. doi: 10.1158/0008-5472.CAN-22-1858.

Abstract

Comprehensive profiling of the enhancer landscape and 3D genome structure in liposarcoma identifies extensive enhancer-oncogene coamplification and enhancer hijacking events, deepening the understanding of how oncogenes are regulated in cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Enhancer Elements, Genetic
  • Humans
  • Liposarcoma*
  • Oncogenes*