Parainfluenza virus 5 is a next-generation vaccine vector for human infectious pathogens

J Med Virol. 2023 Mar;95(3):e28622. doi: 10.1002/jmv.28622.

Abstract

Parainfluenza virus 5 (PIV5) is a negative-sense, single-stranded RNA virus that can infect humans and many species of animals. Infection in these reservoir hosts is generally asymptomatic and has few safety concerns. Emerging evidence has shown that PIV5 is a promising vector for developing vaccines against human infectious diseases caused by coronaviruses, influenza, respiratory syncytial virus, rabies, HIV, or bacteria. In this review, we summarize recent progress and highlight the advantages and strategies of PIV5 as a vaccine vector to improve future vaccine design and application for clinical trials.

Keywords: PIV5; human infectious pathogens; vaccine.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Influenza Vaccines*
  • Influenza, Human*
  • Parainfluenza Virus 3, Human
  • Parainfluenza Virus 5* / genetics
  • Rabies Vaccines*
  • Respiratory Syncytial Virus, Human* / genetics

Substances

  • Influenza Vaccines
  • Rabies Vaccines