Role of the skin microbiota and intestinal microbiome in rosacea

Weitao Zhu; Michael R Hamblin; Xiang Wen

doi:10.3389/fmicb.2023.1108661

Role of the skin microbiota and intestinal microbiome in rosacea

Front Microbiol. 2023 Feb 10:14:1108661. doi: 10.3389/fmicb.2023.1108661. eCollection 2023.

Authors

Weitao Zhu¹, Michael R Hamblin², Xiang Wen³

Affiliations

¹ Clinical Medicine (Eight-Year Program), West China School of Medicine, Sichuan University, Chengdu, China.
² Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South Africa.
³ Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.

Abstract

Rosacea is a chronic inflammatory cutaneous disorder of uncertain etiology that mainly affects the centrofacial region, including cheeks, nose, chin, forehead, and eyes. The pathogenesis of rosacea remains unclear because it involves several complex factors. Additionally, the potential treatment methods need to be explored. We reviewed the common bacterial species in the skin microbiota and gut microbiota of rosacea patients such as Demodex folliculorum, Staphylococcus epidermidis, Bacillus oleronius, Cutibacterium acnes, and Helicobacter pylori and identified their role in the pathogenesis. Besides, we summarized the influence factors such as temperature and age on rosacea patients. We also systematically reviewed the commonly used clinical treatment methods, including antibiotics, probiotics. as well as their treatment mechanism and application precautions.

Keywords: gastrointestinal microbiome; influence factors; rosacea; skin microbiota; treatment.

Publication types

Review