Metabonomic analysis of human and 12 kinds of livestock mature milk

Zeying Wang; Yinggang Sun; Yanzhi Wu; Rui Chen; Yanan Xu; Yafei Cai; Min Chu; Xingtang Dou; Yu Zhang; Yuting Qin; Ming Gu; Yanjun Qiao; Qiu Zhang; Qian Li; Xiaowei Wang; Junrui Wu; Rina Wu

doi:10.1016/j.fochx.2023.100581

Metabonomic analysis of human and 12 kinds of livestock mature milk

Food Chem X. 2023 Jan 20:17:100581. doi: 10.1016/j.fochx.2023.100581. eCollection 2023 Mar 30.

Authors

Zeying Wang^{1

2}, Yinggang Sun¹, Yanzhi Wu¹, Rui Chen¹, Yanan Xu¹, Yafei Cai³, Min Chu⁴, Xingtang Dou⁵, Yu Zhang¹, Yuting Qin¹, Ming Gu¹, Yanjun Qiao¹, Qiu Zhang¹, Qian Li¹, Xiaowei Wang¹, Junrui Wu², Rina Wu²

Affiliations

¹ College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China.
² College of Food Science, Shenyang Agricultural University, Shenyang 110866, China.
³ College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
⁴ Lanzhou Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.
⁵ Liaoning Province Modern Agricultural Production Base Construction Engineering Center. Shenyang 110000, China.

Abstract

Mature milk, as a nutrient-rich endogenous metabolite, has various beneficial effects on the human body. In order to investigate the specific nutrients provided by different dairy products to humans, we used UHPLC-Q-TOF MS to analyze the highly significantly differentially expressed metabolites in 13 species of mammalian mature milk, which were grouped into 17 major metabolite classes with 1992 metabolites based on chemical classification. KEGG shows that 5 pathways in which differentially significant metabolites are actively involved are ABC transporters, Purine metabolism, Pyrimidine metabolism, Phosphotransferase system, Galactose metabolism. The study found that pig milk and goat milk are closer to human milk and contain more nutrients that are beneficial to human health, followed by camel milk and cow milk. In the context of dairy production, the development of goat milk is more likely to meet human needs and health.

Keywords: (-)-riboflavin (PubChem CID6759); Allantoin (PubChem CID204); Erythritol (PubChem CID222285); Glucose 1-phosphate (PubChem CID65533); Goat milk; Hypoxanthine (PubChem CID135398638); Inosine; Inosine (PubChem CID135398641); Maltitol (PubChem CID493591); Metabolomics; Pig milk; Taurine (PubChem CID1123); Uracil (PubChem CID1174); d-Mannose; d-mannose (PubChem CID18950).