Role of miRNAs in mediating organophosphate compounds induced toxicity

Hamideh Dehghan; Tahereh Farkhondeh; Majid Darroudi; Shahnaz Yousefizadeh; Saeed Samarghandian

doi:10.1016/j.toxrep.2023.01.007

Role of miRNAs in mediating organophosphate compounds induced toxicity

Toxicol Rep. 2023 Jan 19:10:216-222. doi: 10.1016/j.toxrep.2023.01.007. eCollection 2023.

Authors

Hamideh Dehghan¹, Tahereh Farkhondeh², Majid Darroudi³, Shahnaz Yousefizadeh⁴, Saeed Samarghandian⁵

Affiliations

¹ Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
² Department of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.
³ Department of Basic Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
⁴ Department of Laboratory and Clinical Sciences, Faculty of Paraveterinary, Ilam University, Ilam, Iran.
⁵ Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran.

Abstract

Organophosphate compounds (OPCs) are a diverse class of chemicals utilized in both industrial and agricultural settings. The exact molecular pathways that OPCs-induced toxicity is caused by are still being investigated, despite the fact that studies on this topic have been ongoing for a long time. As a result, it's important to identify innovative strategies to uncover these processes and further the understanding of the pathways involved in OPCs-induced toxicity. In this context, determining the role of microRNAs (miRs) in the toxicity caused by OPCs should be taken into consideration. Recent research on the regulation function of miRs presents key discoveries to identify any gaps in the toxicity mechanisms of OPCs. As diagnostic indicators for toxicity in people exposed to OPCs, various expression miRs can also be used. The results of experimental and human studies into the expression profiles of miRs in OPCs-induced toxicity have been compiled in this article.

Keywords: MicroRNAs (miRs); Organophosphate compounds; Toxicity.

Publication types

Review