Nanosystems for oxidative stress regulation in the anti-inflammatory therapy of acute kidney injury

Yue Wang; Hong Jiang; Longyao Zhang; Peng Yao; Shaoqing Wang; Qian Yang

doi:10.3389/fbioe.2023.1120148

Nanosystems for oxidative stress regulation in the anti-inflammatory therapy of acute kidney injury

Front Bioeng Biotechnol. 2023 Feb 9:11:1120148. doi: 10.3389/fbioe.2023.1120148. eCollection 2023.

Authors

Yue Wang^{1

2}, Hong Jiang^{1

2}, Longyao Zhang^{1

2}, Peng Yao¹, Shaoqing Wang¹, Qian Yang^{1

2}

Affiliations

¹ The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, China.
² Center of Scientific Research, Chengdu Medical College, Chengdu, Sichuan, China.

Abstract

Acute kidney injury (AKI) is a clinical syndrome that results from a rapid decline in renal structure or renal functional impairment with the main pathological feature of sublethal and lethal damage to renal tubular cells. However, many potential therapeutic agents cannot achieve the desired therapeutic effect because of their poor pharmacokinetics and short retention time in the kidneys. With the recent emergence and progress of nanotechnology, nanodrugs with unique physicochemical properties could prolong circulation time, enhance efficient targeted delivery, and elevate the accumulation of therapeutics that can cross the glomerular filtration barrier and indicate comprehensive application prospects in the prevention and treatment of AKI. In this review, various types of nanosystems (such as liposomes, polymeric nanosystems, inorganic nanoparticles and cell-derived extracellular vesicles) are designed and applied to improve the pharmacokinetics of drug formation, which could further relieve the burden on the kidneys caused by the final cumulative dose of drugs in conventional treatments. Moreover, the passive or active targeting effect of nanosystems can also reduce the total therapeutic dose and off-target adverse effects on other organs. Nanodelivery systems for treating AKI that alleviate oxidative stress-induced renal cell damage and regulate the inflammatory kidney microenvironment are summarized.

Keywords: ROS scavenging; acute kideny injury; anti-inflammtory; nanosystem; oxidative stress.

Publication types

Review

Grants and funding

National Natural Science Foundation of China (grant number: NSFC31600811); the Science and Technology Program for Distinguished Young Scholar of Sichuan Province (grant number: 2020JDJQ0048); the CNNC 2021 Key Project of “Nuclear Medicine Science and Technology Innovation” (grant number: ZHYLZD2021005); the Zhong guancun Nephropathy Blood Purification Innovation Alliance CKD Youth Research Fund (grant number: NBPIA20QC0202); the Chengdu Medical Research Project form Chengdu Municipal Health Commission (grant numbers: 2022324 and 2021056).